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Wątek: NATURALNE sposoby optymalizacji CIAŁA i DUSZY.

  1. #1216
    Smalec prozapalny. Czas umierac

  2. #1217
    do dzieci Neostrady, Mikrofalowych Chłopców, Upośledzonych Fotonem Rycerzy Nowych Technologii,



    zabawy z lewą falą elektromagnetyczną kończą się tragicznie, po lecie przyjdzie jesień



    nie doliczycie się zgonów, tragedia się zacznie jak kostucha przyjdzie do Waszych rodzin.
    Może byś ostro i bez trzymanki. Sraka się poleje po spodniach.

    sezonem zarządza RAKOTWÓRCZA FALA ELEKTROMEGNETYCZNA



    Melatonina to nie tabletka ułatwiająca sen, którą kupujesz w aptece, tylko hormon produkowany przez szyszynkę, który ma odwzorować określony sezon i powiedzieć fizjologicznie którą jest godzina.





    Zmiany sezonowe są rejestrowane również na samym słońcu
    https://earthsky.org/space/scientist...ability-on-sun

    ale nas interesuje jak odwzorować jesień i zimę żeby ciało było przygotowanei mogło adekwatnie reagować.


    https://www.melatonin-research.net/i...le/view/55/400

    metabolizm się zmienia drastycznie - delikatne dusze wiedzą o czym mówię bo swoje wycierpią.


    https://joe.bioscientifica.com/view/.../222/2/R39.xml

    jednym słowem jak będziesz sobie siedział w cieplutkim domku całą jesień oraz zimę dzień/noc przed TV z idealną dietą bogatą we wszystko co trzeba, idealnie zbilansowaną i Bóg wie co - czeka Cie porażka. Liczenie zgonów i szykowanie zmyślnych wykresów nie pomoże.

    Trzeba myśleć o sobie i bliskich bo prawdopodobny wpierdol się pojawi.


    Jeśli zdrowy rozsądek Cie nie może przekonać,
    nauka Cię nie przekona:
    https://clinicaltrials.gov/ct2/show/NCT04353128
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102583/

    to może sztuczna inteligencja która właśnie wpadła na podobny pomysł ?

    kieszonka na ligandzie idealnie pasuje, zobacz



    MELATONIN AS A POTENTIAL COMPOUND AGAINST SARS-COV-2
    https://www.acellera.com/covid19
    Ostatnio edytowane przez htw ; 13-05-20 o 19:33
    correlation doesn't imply causation

  3. #1218
    Cytat Zamieszczone przez maly mis Zobacz posta
    Smalec prozapalny. Czas umierac
    correlation doesn't imply causation

  4. #1219
    Intermittent fasting, a possible priming tool for host defense against SARS-CoV-2 infection:
    crosstalk among calorie restriction, autophagy and immune response


    ABSTRACT
    Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative pathogen of
    deadly Coronavirus disease-19 (COVID-19) pandemic, which emerged as a major threat to public
    health across the world. Although there is no clear gender or socioeconomic discrimination in the
    incidence of COVID-19, individuals who are older adults and/or with comorbidities and
    compromised immunity have a relatively higher risk of contracting this disease. Since no specific
    drug has yet been discovered, strengthening immunity along with maintaining a healthy living is
    the best way to survive this disease. As a healthy practice, calorie restriction in the form of
    intermittent fasting in several clinical settings has been reported to promote several health benefits,
    including priming of the immune response. This dietary practice also activates autophagy, a cell
    surveillance system that boosts up immunity. With these prevailing significance in priming host
    defense, intermittent fasting could be a potential strategy amid this outbreak to fighting off SARSCoV-2 infection. Currently, no review so far available proposing intermittent fasting as an
    encouraging strategy in the prevention of COVID-19. A comprehensive review has therefore been
    planned to highlight the beneficial role of fasting in immunity and autophagy, that underlie the
    possible defense against SARS-CoV-2 infection. The COVID-19 pathogenesis and its impact on
    host immune response have also been briefly outlined. This review aimed at revisiting the
    immunomodulatory potential of intermittent fasting that may constitute a promising preventive
    strategy against COVID-19.

    https://t.co/PYUZ5bjkS7?amp=1


    Dieta i witamina C wspomagają walkę z nowotworami z mutacją KRAS

    Niskokaloryczne diety w połączeniu z witaminą C ułatwiają walkę z agresywnymi nowotworami z mutacją KRAS, donoszą na łamach Nature naukowcy w Uniwersytetów w Mediolanie, Genui oraz Uniwersytetu Kalifornijskiego w Irvine. W swoich badaniach skupili się oni na wpływie takiego połączenia na leczenie raka jelita grubego, jednak nie wykluczają, że odpowiednia dieta wspomagana witaminą C poprawia wyniki chemioterapii w innych nowotworach z mutacją KRAS.
    https://kopalniawiedzy.pl/witamina-C...-grubego,32024

    i mała ciekawostka

    Color of cells a 'thermometer' for molecular imbalance, study finds



    Non-invasive color analysis of cells could one day be used in diagnostics, a proof-of-concept study has shown.
    An imbalance of unstable molecular species called 'free radicals' will change the color of cells—and a new imaging technique could one day allow scientists to detect and decode this color without needing to take samples from the body, a new study by UNSW Sydney researchers has found. The paper was published online yesterday in Redox Biology.
    https://phys.org/news/2020-05-cells-...imbalance.html
    correlation doesn't imply causation

  5. #1220
    Ostatnio edytowane przez htw ; 14-05-20 o 14:30
    correlation doesn't imply causation

  6. #1221
    zwłaszcza interesuje mnie to A-TP

    węgle, tłuszcze, białka wszystko to wpływa na tworzenie tego związku, gdyż ATP nie powstaje z niczego

  7. #1222
    May 14, 2020
    Dietary Approaches to Cancer Therapy



    Introduction
    What we eat and how this might affect our health has been a topic of intense interest for millennia. The Greeks and Romans understood the link between food and wellbeing, and diet books promoting moderation as a route to longevity have been with us since the 15th century. Throughout the last 100 years, innumerable dietary experts—some qualified, some not—have advocated virtually every conceivable variation of nutritional input as a cure for obesity and a multitude of other diseases, including cancer. It is evident that nutritional choices can influence the risk of developing certain malignancies, although the mechanistic bases behind these associations are generally poorly understood (Mayne et al., 2016, Steck and Murphy, 2020). Similarly, the concept that diet can influence cancer therapy holds great popular appeal, and about half of all cancer patients change their dietary habits in an effort to improve survival (Zick et al., 2018). Unfortunately, the effectiveness of many of these diets has not been rigorously assessed, and advice in this realm is often not based on solid mechanistic insight. Nevertheless, clear progress is being made, and in this review, we consider how our increasing understanding of cancer metabolism is leading to the development of evidence-based nutritional interventions for cancer therapy.
    full
    https://www.cell.com/cancer-cell/ful...ecsectitle0010

    w temacie wirusów - ciekawe, szybkie, bezbolesne, rozwiązanie dla służy zdrowia

    “The nose is a major reservoir of bacteria, fungi and viruses which can cause serious hospital infections in ICU or following surgery when immune systems of patients are weakened,” stated Dr. Roger Andersen, VP Regulatory and Medical Affairs at Ondine. “Steriwave nasal photodisinfection is capable of eliminating infection-causing pathogens from the nose of patients with a single, rapid, painless treatment. When used prior to surgery, nasal photodisinfection has contributed to 80% reductions in surgical site infections.”

    https://www.smartindustrynews.com/si...ction-therapy/

    Czas fotofarmakologii stawiają pierwsze kroki, na tapecie aktyna, która jest szeroko rozpowszechniana w mieścinach. Fioletowe światło włącza, zielone światło wyłącza.

    Controlling cells with light

    Photopharmacology investigates the use of light to switch the effect of drugs on and off. Now, for the first time, scientific teams from Jena, Munich, and New York have succeeded in using this method to control a component of cells that was previously considered inaccessible.
    https://phys.org/news/2020-05-cells.html

    MAY 14, 2020
    Want to sleep like a baby during the coronavirus crisis? Here are 10 ways to do it

    The crisis created by the COVID-19 pandemic has resulted in a generalized climate of anxiety, which has increased stress levels and which can lead to insomnia even in people who do not usually suffer from it. While it is true that good sleep is essential to health in normal times, it becomes even more so in this period of confinement.
    1. Establish a regular schedule. Regular bedtime and wake-up times will help you maintain a healthy sleep routine.

    2. Keep in contact with natural light. Open your windows and expose yourself to sunlight as much as possible. This can be good for improving your mood and regulating your body clock. In addition, it is an opportunity to get some fresh air in a controlled manner for a short period of time.

    3. Maintain daily physical activity. Staying active during social distancing helps you build up enough body fatigue to fall asleep more easily and get a deeper sleep.

    4. Limit naps. Unless you have had very little sleep the previous night, it is important to avoid sleeping during the day or in the afternoon, as this reduces sleep pressure and increases the risk of insomnia.

    5. Maintain a social life. Bad news in the media can create anxiety. It is important to use your online social networks to seek support from friends and family to keep your spirits up and maintain your mental health. This is especially important when living alone or away from family.

    6. Be disciplined in your diet. Avoid drinking coffee in the afternoon as it can cause nervousness and delay sleep in the evening. Eating large, overly rich meals before going to bed can also delay sleep. Some people have no problem sleeping, even if they drink a lot of coffee and eat a lot. It is nevertheless recommended to control the quantities and times of consumption during the day because anything in excess may harm sleep.

    7. Avoid backlit devices before bedtime. New technologies are an integral part of our lives and we're all a little addicted to our smartphones, tablets and laptops. It is absolutely important to set them aside at least 30 minutes before your scheduled sleep time. If you're worried you won't be able to do that, you can set the device to "night mode" to reduce its brightness. By reducing the brain's lag with the natural cycle of day and night, this will prevent disturbances in the biological clock and will be beneficial for the quality of sleep in the long term.

    8. Avoid staying in bed if you don't sleep. The brain is like a computer, which associates certain events with certain functions. The brain will associate bed and darkness with sleep and trigger the whole process of falling asleep. The brain will not be able to do this if it is distracted by other activities such as video games, homework, physical activity and alcohol. It is best to read a book, listen to soft music, do deep breathing exercises or yoga, or any other relaxing activity. Do not stay in bed for more than half an hour after going to bed if you are not sleeping. When sleep is delayed, it is best to get out of bed, do a quiet activity, and return to bed only when signs of fatigue—heavy eyelids, yawning, etc.—appear.

    9. Accept that not all our nights of sleep are perfect or restful. We are all subject to stress and each of us has our own stress management techniques. We must avoid worrying if we haven't slept well for a few days. Before you get upset about poor sleep, I suggest you review the eight recommendations above. Often, people have trouble sleeping because of a trivial problem, an argument with a loved one, or work-related anxiety. Identifying your stress and learning how to manage it is a good start.

    10. Avoid sleeping pills. Generally, the easy solution is the one that carries the most risk. Prolonged use of sleep aids, such as benzodiazepines or anxiolytics, without consulting health-care professionals could worsen a situation that was not initially serious. It is better to adopt a healthy lifestyle than to resort to medication, both in normal situations and during confinement due to COVID-19.
    https://medicalxpress.com/news/2020-...isis-ways.html

    niezbędne poranne słońce, pomyślcie o jesieni czego Wam zabranie ?

    Bmal1 integrates mitochondrial metabolism and macrophage activation

    Metabolic pathways and inflammatory processes are under circadian regulation. While rhythmic immune cell recruitment is known to impact infection outcomes, whether the circadian clock modulates immunometabolism remains unclear. We find the molecular clock Bmal1 is induced by inflammatory stimulants, including Ifn-g/lipopolysaccharide (M1) and tumor-conditioned medium, to maintain mitochondrial metabolism under these metabolically stressed conditions in mouse macrophages. Upon M1 stimulation, myeloid-specific Bmal1 knockout (M-BKO) renders macrophages unable to sustain mitochondrial function, enhancing succinate dehydrogenase (SDH)-mediated mitochondrial ROS production and Hif-1a-dependent metabolic reprogramming and inflammatory damage. In tumor-associated macrophages, the aberrant Hif-1a activation and metabolic dysregulation by M-BKO contribute to an immunosuppressive tumor microenvironment. Consequently, M-BKO increases melanoma tumor burden, while administrating an SDH inhibitor dimethyl malonate suppresses tumor growth. Therefore, Bmal1 functions as a metabolic checkpoint integrating macrophage mitochondrial metabolism, redox homeostasis and effector functions. This Bmal1-Hif-1a regulatory loop may provide therapeutic opportunities for inflammatory diseases and immunotherapy.
    https://elifesciences.org/articles/54090


    jakby ktoś nie wiedział, a chciałby poczytać, doczytać, ten związek był dopieszczany przez miliardy lat, nie warto być mądrzejszym.

    Melatonin Research


    http://www.melatonin-research.net/index.php/MR

    ciekawostki:

    padaczka,
    zegarowa higiena sprawa podstawowa
    https://www.ncbi.nlm.nih.gov/pubmed/...?dopt=Abstract

    malaria ma swój zegar:
    https://www.sciencedaily.com/release...0514143538.htm
    correlation doesn't imply causation

  8. #1223
    tą malarie rozumiem na dwa sposoby nie wiem czy dobrze

  9. #1224
    mitochondria pochłaniają fale elektromagnetyczną, co owocuje bezpośrednim wzrostem wydajność.
    Jak się okazuje, można również działać pośrednio poprzez witaminę D. Różnica wydajności w przepływie elektronów przez łańcuch jest kosmiczny ~35%. To badania na myszach mutantach z podawaną w postaci suplementu metabolitem, starch się bać jak to wygląda w naturze

    Diet-Induced Vitamin D Deficiency Results in Reduced Skeletal Muscle
    2 Mitochondrial Respiration in C57BL/6J Mice


    Vitamin D deficiency is known to be associated with symptoms of skeletal muscle myopathy including muscle weakness and fatigue. Recently, vitamin D related metabolites have been linked to the maintenance of mitochondrial function within skeletal muscle. However, current evidence is limited to in vitro models and the effects of diet-induced vitamin D deficiency upon skeletal muscle mitochondrial function in vivo have received little attention. In order to examine the role of vitamin D in the maintenance of mitochondrial function in vivo, we utilised an established model of diet-induced vitamin D deficiency in C57BL/6J mice. Mice were fed either a control (2,200 IU/kg) or a vitamin D deplete (0 IU/kg) diet for periods of 1-, 2- and 3-months. Skeletal muscle mitochondrial function and ADP sensitivity were assessed via high-resolution respirometry and mitochondrial protein content via immunoblotting. As a result of 3-month of diet-induced vitamin D deficiency, respiration supported via CI+IIP and ETC were 35% and 37% lower when compared to vitamin D replete mice (P < 0.05). Despite functional alterations, the protein expression of electron transfer chain subunits remained unchanged in response to dietary intervention (P > 0.05). In conclusion, we report that 3-months of diet-induced vitamin D deficiency reduced skeletal muscle mitochondrial function in C57BL/6J mice. Our data, when combined with previous in vitro observations, suggests that vitamin D mediated regulation of mitochondrial function may underlie the exacerbated muscle fatigue and performance deficits observed during vitamin D deficiency.
    https://www.biorxiv.org/content/10.1...087v1.full.pdf

    przy okazji diety zimowej

    Ketogenic Diet-Induced Weight Loss is Associated with an Increase in Vitamin D Levels in Obese Adults
    https://www.mdpi.com/1420-3049/24/13/2499/htm

    a czemu wydajność kompleksu jest ważna? bo jaka wydajność taka odporność

    Mitochondrial respiratory capacity modulates LPS-induced inflammatory signatures in human blood
    https://www.sciencedirect.com/scienc...454?via%3Dihub

    i jeszcze jedna ciekawa hipoteza.
    Mechanizm oporności na insulinę może być narzędziem adaptacyjnym chroniącym mięśnie przed najazdem glukozy

    Insulin Resistance as a Physiological Defense Against Metabolic Stress: Implications for the Management of Subsets of Type 2 Diabetes
    https://diabetes.diabetesjournals.org/content/64/3/673
    +
    Effects of a Hypercaloric and Hypocaloric Diet on Insulin-Induced Microvascular Recruitment, Glucose Uptake, and Lipolysis in Healthy Lean Men
    https://www.ahajournals.org/doi/10.1...AHA.120.314129


    tutaj przykład skrajny, ale pomyśleć ile można zrobić jednym ruchem - zwyczajnie wyłączając światło

    Melatonin supplementation and the effects on clinical and metabolic status in Parkinson's disease: A randomized, double-blind, placebo-controlled trial.
    https://www.ncbi.nlm.nih.gov/pubmed/...?dopt=Abstract

    i jak pisałem nie ma co kombinować,



    lubisz kolorowe napoje? - licz się z konsekwencjami
    Sugar‐Sweetened Beverage Intake and Cardiovascular Disease Risk in the California Teachers Study
    https://www.ahajournals.org/doi/10.1161/JAHA.119.014883
    correlation doesn't imply causation

  10. #1225
    wraz z wiekiem zapotrzebowanie na pełno spektralna fale elektromagnetyczną rośnie

    Regulation of vitamin D system in skeletal muscle and resident myogenic stem cell during development, maturation, and ageing
    https://www.nature.com/articles/s41598-020-65067-0


    problemy z jelitami, wyłącz światło po zachodzie

    Melatonin Attenuates Microbiota Dysbiosis of Jejunum in Short-Term Sleep Deprived Mice

    Our study demonstrated that sleep deprivation resulted in homeostasis disorder of colon. Our study goes deeper into the positive effects of melatonin on small intestinal microbiota disorder caused by sleep deprivation. We successfully established a multiplatform 72 h sleep deprivation mouse model with or without melatonin supplementation, and analyzed the change of small intestinal microbiota using high-throughput sequencing of the 16S rRNA. We found melatonin supplementation suppressed the decrease of plasma melatonin level in sleep deprivation mice. Meanwhile, melatonin supplementation improved significantly the reduction in OTU numbers and the diversity and richness of jejunal microbiota and the abundance of Bacteroidaeae and Prevotellaceae, as well as an increase in the Firmicutes-to-Bacteroidetes ratio and the content of Moraxellaceae and Aeromonadaceae in the jejunum of sleep deprived-mice. Moreover, melatonin supplementation reversed the change of metabolic pathway in sleep deprived-mice, including metabolism, signal transduction mechanisms and transcription etc, which were related to intestinal health. Furthermore, melatonin supplementation inverted the sleep deprivation-induced a decline of anti-inflammatory cytokines (IL-22) and an increase of the ROS and proinflammatory cytokines (IL-17) in jejunum. These findings suggested that melatonin, similar to a probiotics agent, can reverse sleep deprivation-induced small intestinal microbiota disorder by suppressing oxidative stress and inflammation response.
    https://pubmed.ncbi.nlm.nih.gov/32424577/?dopt=Abstract

    Walking or cycling to work associated with reduced risk of early death and illness
    https://medicalxpress.com/news/2020-...h-illness.html

    Exercise improves memory, boosts blood flow to brain
    https://medicalxpress.com/news/2020-...ood-brain.html

    Higher fiber saves lives, but food processing may remove benefits
    https://medicalxpress.com/news/2020-...-benefits.html

    i znowu jelita i stany zapalne o podłożu autoimmunologii - dieta zimowa w natarciu !

    Ketogenic diets alter gut microbiome in humans, mice



    Low-carb, high-fat ketogenic diets, which have attracted public interest in recent years for their proposed benefits in lowering inflammation and promoting weight loss and heart health, have a dramatic impact on the microbes residing in the human gut, collectively referred to as the microbiome, according to a new UC San Francisco study of a small cohort of volunteer subjects. Additional research in mice showed that so-called "ketone bodies," a molecular byproduct that gives the ketogenic diet its name, directly impact the gut microbiome in ways that may ultimately suppress inflammation, suggesting evidence for potential benefits of ketone bodies as a therapy for autoimmune disorders affecting the gut.
    https://medicalxpress.com/news/2020-...me-humans.html

    i znowu na zimowe depresje - podejście sezonowe, YO !

    Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula
    https://www.sciencedirect.com/scienc...89159120301367

    i na koniec oszołom Leszczyński



    całość:
    https://instytutsprawobywatelskich.p...ac-raka-mozgu/
    correlation doesn't imply causation

  11. #1226
    Robert hass
    dietetyk cher
    ale tytułu nie pamiętam, książka ciekawa podobna o tej o dopaminie, którą przejrzałem tylko bo słaba
    Ostatnio edytowane przez arczibald ; 20-05-20 o 23:32

  12. #1227
    wg mnie bardzo ciekawa, dużo tłumaczy
    (ciekawa koncepcja genu DRD4 na allelu 7 w kontekście sporów politycznych )

    onkogen ALK (anaplastic lymphoma kinase ) sprawia, że pewien niewielki fragment ludzi może jeść do woli bez metabolicznych konsekwencji (tutaj ostro powiedziane).

    Scientists identify gene linked to thinness that may help resist weight gain
    https://medicalxpress.com/news/2020-...ss-resist.html




    Associations of Sleep Duration and Quality With Serum and Hepatic Lipids: The Netherlands Epidemiology of Obesity Study

    Short and long sleep duration and poor sleep quality may affect serum and hepatic lipid content, but available evidence is inconsistent. Therefore, we aimed to investigate the associations of sleep duration and quality with serum and hepatic lipid content in a large population-based cohort of middle-aged individuals. The present cross-sectional study was embedded in the Netherlands Epidemiology of Obesity (NEO) study and consisted of 4260 participants (mean age, 55 years; proportion men, 46%) not using lipid-lowering agents. Self-reported sleep duration and quality were assessed using the Pittsburgh Sleep Quality Index questionnaire (PSQI). Outcomes of this study were fasting lipid profile (total cholesterol, low-density lipoprotein [LDL]-cholesterol, high-density lipoprotein [HDL]-cholesterol and triglycerides), postprandial triglyceride (response) levels, and hepatic triglyceride content (HTGC) as measured with magnetic resonance spectroscopy. We performed multivariable linear regression analyses, adjusted for confounders and additionally for measures that link to adiposity (e.g. body mass index [BMI] and sleep apnea). We observed that relative to the group with median sleep duration (≈7.0 hr of sleep), the group with shortest sleep (≈5.0 hr of sleep) had 1.5-fold higher HTGC (95% confidence interval [CI]: 1.0-2.2). The group with PSQI score ≥ 10 had a 1.1-fold (95% CI: 1.0-1.2) higher serum triglyceride level compared with the group with PSQI ≤ 5. However, these associations disappeared after adjustment for BMI and sleep apnea. Therefore, we concluded that previously observed associations of shorter sleep duration and poorer sleep quality with an adverse lipid profile, may be explained by BMI and sleep apnea, rather than by a direct effect of sleep on the lipid profile.
    dwa klucze środowiskowe, światło i temperatura

    A clue as to why it's so hard to wake up on a cold winter's morning

    Winter may be behind us, but do you remember the challenge of waking up on those cold, dark days? Temperature affects the behavior of nearly all living creatures, but there is still much to be learned about the link between sensory neurons and neurons controlling the sleep-wake cycle.
    https://medicalxpress.com/news/2020-...r-morning.html

    bioelektryka coraz wyraźniejsza

    A new understanding of everyday cellular processes
    https://phys.org/news/2020-05-everyday-cellular.html

    'Water wires' may play bigger role in cellular function
    https://phys.org/news/2020-05-wires-...-function.html

    i na koniec zagadka,

    gówno żarcie zapakowane w gówno opakowanie powoduje ?
    https://chemtrust.org/fcm-revision-announced/

    problem jest ignorowany ale bardzo realny
    https://news.wsu.edu/2019/12/05/stud...nderestimated/

    i do poduszki kolejny oszołom

    Dr. Paolo Cassano is assistant professor of psychiatry at Harvard Medical School and Director of Photobiomodulation at the Massachusetts General Hospital (MGH) Depression and Clinical Research Program and Principal Investigator at the MGH Center for Anxiety and Traumatic Stress Disorders.


    uprzedzając pytania, ale jak ? własnie tak

    Ostatnio edytowane przez htw ; 21-05-20 o 18:15
    correlation doesn't imply causation

  13. #1228
    lubisz szybkie wysokokaloryczne żarcie ? myślisz strzał w kolano - niestety jest dużo gorzej - bo strzał jest wycelowany troszkę wyżej


    Effects of short-term exposure to high-fat diet on histology of male and female gonads in rats

    Obesity, which reaches an epidemic, is characterized by alterations in metabolic and hormonal profiles. Moreover, uncontrolled obesity may lead to development of diabetes type 2, which accounts for about 90% of all diabetic cases. In obesity, besides changes in metabolism, numerous co-morbidities are reported, e.g. disruptions of reproductive functions. Additionally, sex differences in development of this disease occur.

    We hypothesized that short-term exposure to high-fat diet (HFD; containing 50% of total energy from fat) would alter histology of testes and ovaries, and thus contribute to reproductive disruptions in male and female rats. Adult rats were fed ad libitum with HFD for 6–7 weeks and its effects on histology of testes and ovaries (n = 4/sex and treatment group) were studied using hematoxylin-eosin staining followed by microscopic analysis and compared to control (laboratory chow fed) group.
    We have found that in male rats fed with HFD there were: 1) decrease in diameter of seminiferous tubules due to smaller luminar diameter, and no change in epithelium height; 2) decrease in number of Sertoli cells; 3) no changes in number of spermatogonia and in percentage of semen in seminiferous tubules. In female rats exposed to HFD we have seen: 1) decrease in diameters of corpora lutea; 2) decrease in diameter of ovarian follicles types 7 and 8, but no changes in their number; 3) no changes in number of early primary follicles, primary follicles, and secondary follicles.

    We concluded that relatively short-term exposure to HFD in rats leads to changes in histology of both testes and ovaries, thus affecting reproductive functions.
    https://www.sciencedirect.com/scienc...X?dgcid=author

    a jak już jestem zmuszony to lepiej używaj przypraw. Magiczna mieszanka wg naukowaców:

    mieszanka bazylii, liścia laurowego, czarnego pieprzu , cynamonu, kolendry, kminku, imbiru, oregano, pietruszki, czerwonej papryki, rozmarynu, tymianku i kurkumy
    Adding a blend of spices to a meal may help lower inflammation
    https://medicalxpress.com/news/2020-...lammation.html

    postawa podczas odpoczynku również warta uwagi ! kupujemy kamień i troszkę ziemi na Allegro, często stosujemy przykuc słowiański i jest git a dla wszystkich co z piwnicy nie chce wyjść jest również nowe rozwiązanie , sztuczne okno SunnyFive cywilizacja gówno poziom ekspert.

    To nie siedzący tryb życia, a postawa podczas odpoczynku jest głównym problemem

    Brak aktywności fizycznej to wielki problem współczesnych społeczeństw. Nauka wiąże z siedzącym trybem życia coraz więcej problemów zdrowotnych, co skłania część badaczy do wysunięcia hipotezy, że nasze organizmy nie są ewolucyjnie przystosowane do takiego trybu życia. Jednak z najnowszych badań wynika, że współcześni łowcy-zbieracze spędzają na siedząco tyle samo czasu co mieszkańcy krajów uprzemysłowionych.

    Na łamach PNAS ukazał się artykuł autorstwa naukowców z Uniwersytetu Południowej Kalifornii, Duke University, Uniwersytetu Kalifornijskiego w Los Angeles, University of Houston i Uniwersytetu w Dar es-Salaam, którego autorzy informują o wynikach swoich badań prowadzonych na plemieniu Hadza. Piszą w nim, że łowcy-zbieracze spędzają równie dużo czasu w pozycji siedzącej, co ludzie z krajów uprzemysłowionych. Jednak czas, jaki łowcy-zbieracze spędzają w pozycji siedzącej jest często spędzany w pozycjach takich jak kucki, które wymuszają większą aktywność mięśni niż podczas siedzenia na krześle. Dlatego też uważamy, że ludzka fizjologia ewoluowała z uwzględnieniem długich okresów braku aktywności, ale ze zwiększoną aktywnością mięśniową w czasie siedzenia. To zaś sugeruje, że negatywne skutki braku aktywności mają związek z pozycją siedzenia na krześle we współczesnych społeczeństwach uprzemysłowionych.

    Z siedzącym trybem życia wiążą się takie negatywne zjawiska zdrowotne jak zanik masy mięśniowej i związana z tym redukcja metabolizmu mięśniowego. Występowanie tych ryzyk to paradoks, gdyż presja ewolucyjna faworyzuje minimalizowanie wydatkowania energii.

    Dlatego też naukowcy postanowili przyjrzeć się współczesnym łowcom-zbieraczom, plemieniu Hadza z Tanzanii, by lepiej zrozumieć okresy braku aktywności u nieuprzemysłowionych społeczeństw. Chcieli w ten sposób zbadać hipotezę mówiącą, że niezwiązane ze spacerowaniem okresy odpoczynku u łowców zbieraczy wymagają aktywności mięśniowej różnej od aktywności związanej z siedzeniem na krześle, typowym dla społeczeństw uprzemysłowionych.

    Szczegółowe badania wykazały, że mediana czasu braku aktywności fizycznej u dorosłych Hadza wynosi – nie licząc okresu snu – 9,9 godziny na dobę (± 2,36 godziny), czyli jest podobna do okresu braku aktywności w społeczeństwach uprzemysłowionych. Z innych badań wiemy bowiem, że np. w Holandii dorośli spędzają w pozycji siedzącej średnio 9,3 godziny na dobę, w USA jest to 9,0 godziny, a w Australi – 8,8 godziny. Co więcej, okresy intensywnej aktywności fizycznej podczas siedzenia wynoszą o u Hadza 15,22 (±8,77 ) minuty na dobę, czyli są podobne do takich samych okresów aktywności np. u Europejczyków (11,1, ±3,5 minuty). Również liczba dziennych zmian pozycji pomiędzy siedzącą, a aktywną, która wynosi u Hadza 49,98 (±15,57) jest podobna do takich zmian u Europejsczyków (37,6, ±8,5).

    Jednak dorośli Hadza podczas okresów braku aktywności fizycznej przyjmują zupełnie inne pozycje, niż dorośli w krajach uprzemysłowionych. Najczęściej siedzą na ziemi. Jednak średnio 18% czasu braku aktywności fizycznej spędzają w kucki, a 12,5% czasu klęcząc. A pozycje te wymagają większej aktywności mięśni nóg. Na przykład podczas siedzenia w kucki, gdy pięty spoczywają na ziemi, a człowiek siedzi na małym kamieniu, zauważono większą aktywność mięśni płaszczkowatych niż podczas siedzenia na krześle. Z kolei w czasie pełnego siedzenia w kucki, gdy pięty dotykają ziemi, a pośladki znajdują się nad ziemią i nie są niczym podparte, dochodzi do zwiększonej aktywności mięśni płaszczkowatych, mięśni obszernych bocznych oraz mięśni piszczelowych przednich.

    Pomimo tego, że okresy braku aktywności u Hadza są podobne, co u osób z krajów uprzemysłowionych, u ludu tego niemal nie występują biomarkery ryzyka chorób układu krążenia, takie jak podwyższony poziom cholesterolu, trójglicerydów czy glukozy. Jako, że inne badania, w tym i wcześniejsze prowadzone przez tę samą grupę naukową, wykazały, że częste zmiany pomiędzy umiarkowaną a wysoką aktywnością zmniejszają ryzyko wystąpienia tych biomarkerów, uczeni doszli do interesujących wniosków.

    Naukowcy opracowali Inactivity Mismatch Hypothesis mówiącą, że ludzka fizjologia jest przystosowana do bardziej stałego poziomu aktywności mięśniowej pochodzącej zarówno z aktywności fizycznej jak i z okresów nieaktywności, kiedy to przyjmowane są pozycje wymagające wyższej aktywności niż podczas siedzenia na krześle. Zgodnie z tą hipotezą, społeczeństwa uprzemysłowione szkodzą swojemu zdrowiu nie poprzez wydłużenie okresu braku aktywności fizycznej, ale poprzez nieodpowiednią, niewymuszającą aktywności mięśni, postawę podczas odpoczynku.
    Samsung prezentuje inteligentne sztuczne okna idealnie imitujące światło słoneczne



    Najnowszy pomysł sponsorowany przez Samsunga wydaje się bardzo na czasie, bo mówimy o inteligentnych sztucznych oknach, które są w stanie zastąpić nam wyjście na zewnątrz, co w czasie pandemii koronawirusa może być obarczone ryzykiem. Co ciekawe, nie chodzi tu tylko o wygląd okna, co może swoją drogą przypaść do gustu osobom, które mają w domu tzw. ciemne pomieszczenia, ale i właściwości, które mają wiernie imitować światło słoneczne.
    https://www.geekweek.pl/news/2020-05...tlo-sloneczne/

    czy to się dzieje naprawdę ?

    4 wymiar medycyny - CZAS

    Personalized medicine and circadian rhythms: Opportunities for modern society

    Circadian rhythms govern physiology and metabolism, leading to controlled homeostasis. We discuss the impact of circadian rhythms on society and the challenges for the imminent future of personalized medicine.
    https://rupress.org/jem/article/doi/...cadian-rhythms



    Utrzymywanie mitochondrialnego DNA w komórkach odpornościowych reguluje starzenie się myszy
    https://science.sciencemag.org/conte...cience.aax0860
    correlation doesn't imply causation

  14. #1229
    potrzeba łączenia

    22 May 2020
    Social determinants of health and survival in humans and other animals

    Abstract
    The social environment, both in early life and adulthood, is one of the strongest predictors of morbidity and mortality risk in humans. Evidence from long-term studies of other social mammals indicates that this relationship is similar across many species. In addition, experimental studies show that social interactions can causally alter animal physiology, disease risk, and life span itself. These findings highlight the importance of the social environment to health and mortality as well as Darwinian fitness—outcomes of interest to social scientists and biologists alike. They thus emphasize the utility of cross-species analysis for understanding the predictors of, and mechanisms underlying, social gradients in health.


    Social adversity is closely linked to health and mortality outcomes in humans, across the life course. These observations have recently been extended to other social mammals, in which social integration, social status, and early-life adversity have been shown to predict natural life spans in wild populations and molecular, physiological, and disease outcomes in experimental animal models.
    Effectiveness of cold therapy depends on water temperature, muscle position

    A new study finds that cold water therapy affects blood flow to individual muscles of the leg differently and is dependent on the temperature of the water. The first-of-its-kind study is published ahead of print in the Journal of Applied Physiology.
    https://medicalxpress.com/news/2020-...re-muscle.html

    Diet-derived nutrient patterns and components of metabolic syndrome: a cross-sectional community- based study

    Results
    Three nutrient patterns explaining 53.66% of the variance in dietary nutrients intake, were recognized in the current study. Animal-sourced nutrient pattern was significantly associated with the higher odds of MetS and high triglyceride (TG) levels. Plant-sourced nutrient pattern (high intake of fiber, carbohydrate, vitamins B6, B3, C, B1, E, D, magnesium, potassium, and linoleic acid) was significantly associated with lower risk of MetS and lower blood pressure (p < 0.05). Third nutrient pattern (mixed-source) was significantly related to higher risk of MetS, high waist circumference (WC) and high systolic blood pressure (SBP).

    Conclusion
    This present study confirms the important effect of nutrients and their patterns on MetS risk. Our results suggest that adherence to the nutrient pattern rich in fiber, carbohydrate, vitamins D, B6, B3, C, B1, E, magnesium, potassium, linoleic acid, and docosahexaenoic acid (DHA) is associated with a lower risk of MetS, while animal- and mixed-sourced nutrient patterns are positively associated with greater odds of MetS; However, further longitudinal and interventional studies are required to make a clear conclusion.

    Thiamine = B1
    Ryboflawina = B2
    Niacin = B3
    Pantothenic acid = B5
    Folate B9

    100 g wątróbki



    Impact of Meal Frequency on Anthropometric Outcomes: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

    ABSTRACT
    The relation between meal frequency and measures of obesity is inconclusive. Therefore, this systematic review and network meta-analysis (NMA) set out to compare the isocaloric effects of different meal frequencies on anthropometric outcomes and energy intake (EI). A systematic literature search was conducted in 3 electronic databases (Medline, Cochrane Library, Web of Science; search date, 11 March 2019). Randomized controlled trials (RCTs) were included with ≥2 wk intervention duration comparing any 2 of the eligible isocaloric meal frequencies (i.e., 1 to ≥8 meals/d). Random-effects NMA was performed for 4 outcomes [body weight (BW), waist circumference (WC), fat mass (FM), and EI], and surface under the cumulative ranking curve (SUCRA) was estimated using a frequentist approach (P-score: value is between 0 and 1). Twenty-two RCTs with 647 participants were included. Our results suggest that 2 meals/d probably slightly reduces BW compared with 3 meals/d [mean difference (MD): −1.02 kg; 95% CI: −1.70, −0.35 kg) or 6 meals/d (MD: −1.29 kg; 95% CI: −1.74, −0.84 kg; moderate certainty of evidence). We are uncertain whether 1 or 2 meals/d reduces BW compared with ≥8 meals/d (MD1 meal/d vs. ≥8 meals/d: −2.25 kg; 95% CI: −5.13, 0.63 kg; MD2 meals/d vs. ≥8 meals/d: −1.32 kg; 95% CI: −2.19, −0.45 kg) and whether 1 meal/d probably reduces FM compared with 3 meals/d (MD: −1.84 kg; 95% CI: −3.72, 0.05 kg; very low certainty of evidence). Two meals per day compared with 6 meals/d probably reduce WC (MD: −3.77 cm; 95% CI: −4.68, −2.86 cm; moderate certainty of evidence). One meal per day was ranked as the best frequency for reducing BW (P-score: 0.81), followed by 2 meals/d (P-score: 0.74), whereas 2 meals/d performed best for WC (P-score: 0.96). EI was not affected by meal frequency. In conclusion, our findings indicate that there is little robust evidence that reducing meal frequency is beneficial.
    https://academic.oup.com/advances/ad...dFrom=fulltext
    correlation doesn't imply causation

  15. #1230
    Changes in Biological Pathways During 6,000 Years of Civilization in Europe

    Abstract
    The beginning of civilization was a turning point in human evolution. With increasing separation from the natural environment, mankind stimulated new adaptive reactions in response to new environmental factors. In this paper, we describe direct signs of these reactions in the European population during the past 6,000 years. By comparing whole-genome data between Late Neolithic/Bronze Age individuals and modern Europeans, we revealed biological pathways that are significantly differently enriched in nonsynonymous single nucleotide polymorphisms in these two groups and which therefore could be shaped by cultural practices during the past six millennia. They include metabolic transformations, immune response, signal transduction, physical activity, sensory perception, reproduction, and cognitive functions. We demonstrated that these processes were influenced by different types of natural selection. We believe that our study opens new perspectives for more detailed investigations about when and how civilization has been modifying human genomes.


    Differential SNP enrichment of KEGG pathways between ancient and modern individuals. Positive DNSE values correspond to pathways that have more SNPs in genomes of ancient individuals, whereas negative DNSE values correspond to pathways that have more SNPs in genomes of modern Europeans.
    https://academic.oup.com/mbe/article/36/1/127/5146762

    The Effect of Whole-Grain Intake on Biomarkers of Subclinical Inflammation: A Comprehensive Meta-analysis of Randomized Controlled Trials

    Abstract
    Findings on the effect of whole-grain consumption on inflammatory biomarkers are conflicting. This study aimed to summarize available studies on the effects of whole-grain consumption on inflammatory biomarkers in adults. Online databases including PubMed, Scopus, ISI Web of Science, and Google Scholar were searched for relevant studies published up to January 2018, using relevant keywords. We included randomized controlled trials (RCTs) investigating the effect of whole-grain foods or diets high in whole-grain foods on markers of inflammation. Studies were selected if they had a control diet low in whole grains or diets without whole grains, whether calorie restricted or not. We did not include studies that examined the effect of individual grain components, including bran or germ, or fiber-based diets. Overall, 14 RCTs, with 1238 individuals aged ≥18 y, were included. Pooling 13 effect sizes from 11 RCTs on serum C-reactive protein (CRP) concentrations, we found no significant effect of whole-grain consumption on serum CRP concentrations [weighted mean difference (WMD): -0.29 mg/L; 95% CI: -1.10, 0.52 mg/L]. However, the beneficial effects of whole-grain intake on serum CRP concentrations were observed in studies in individuals with elevated serum concentrations of CRP and studies with isocaloric diets. Combining 11 effect sizes from 10 RCTs, we found no significant effect of whole-grain consumption on serum IL-6 concentrations (WMD: -0.08 pg/mL; 95% CI: -0.27, 0.11 pg/mL). Nevertheless, we observed a significant effect of whole-grain consumption on serum IL-6 concentrations in studies in unhealthy individuals. A nonsignificant effect of whole-grain intake on circulating serum TNF-α concentrations was also seen when we summarized effect sizes from 7 RCTs (WMD: -0.06 pg/mL; 95% CI: -0.25, 0.14 pg/mL). Such a nonsignificant effect was observed for serum concentrations of plasminogen activator inhibitor-1 (PAI-1) (WMD: -3.59; 95% CI: -1.25, 8.44 kU/L). Unlike observational studies, we found no significant effect of whole-grain consumption on serum concentrations of inflammatory cytokines, including serum concentrations of CRP, IL-6, TNF-α, and PAI-1. However, beneficial effects of whole grains were found in some subgroups. Given the high between-study heterogeneity, deriving firm conclusions is difficult.
    https://pubmed.ncbi.nlm.nih.gov/31301131/

    Association of nut intake with risk factors, cardiovascular disease, and mortality in 16 countries from 5 continents: analysis from the Prospective Urban and Rural Epidemiology (PURE) study

    Results
    We followed 124,329 participants (age = 50.7 y, SD = 10.2; 41.5% male) for a median of 9.5 y. We recorded 10,928 composite events [deaths (n = 8,662) or major cardiovascular events (n = 5,979)]. Higher nut intake (>120 g per wk compared with <30 g per mo) was associated with a lower risk of the primary composite outcome of mortality or major cardiovascular event [multivariate HR (mvHR): 0.88; 95% CI: 0.80, 0.96; P-trend = 0.0048]. Significant reductions in total (mvHR: 0.77; 95% CI: 0.69, 0.87; P-trend <0.0001), cardiovascular (mvHR: 0.72; 95% CI: 0.56, 0.92; P-trend = 0.048), and noncardiovascular mortality (mvHR: 0.82; 95% CI: 0.70, 0.96; P-trend = 0.0046) with a trend to reduced cancer mortality (mvHR: 0.81; 95% CI: 0.65, 1.00; P-trend = 0.081) were observed. No significant associations of nuts were seen with major CVD (mvHR: 0.91; 95% CI: 0.81, 1.02; P-trend = 0.14), stroke (mvHR: 0.98; 95% CI: 0.84, 1.14; P-trend = 0.76), or MI (mvHR: 0.86; 95% CI: 0.72, 1.04; P-trend = 0.29).

    Conclusions
    Higher nut intake was associated with lower mortality risk from both cardiovascular and noncardiovascular causes in low-, middle-, and high-income countries.
    https://academic.oup.com/ajcn/advanc...qaa108/5841181

    Microbiome rewilding: Biodiverse urban green spaces strengthen human immune systems

    A research team led by the University of Adelaide has found that revegetation of green spaces within cities can improve soil microbiota diversity towards a more natural, biodiverse state, which has been linked to human health benefits.

    In the study, published in the journal Restoration Ecology, researchers compared the composition of a variety of urban green space vegetation types of varying levels of vegetation diversity, including lawns, vacant lots, parklands, revegetated woodlands and remnant woodlands within the City of Playford Council area in South Australia.
    https://medicalxpress.com/news/2020-...ban-green.html

    +

    Multiple sclerosis risk 29% higher for people living in urban areas, new research reveals

    Air pollution could be a risk factor for the development of multiple sclerosis (MS), a new study conducted in Italy has found.

    The research, presented today at the European Academy of Neurology (EAN) Virtual Congress, detected a reduced risk for MS in individuals residing in rural areas that have lower levels of air pollutants known as particulate matter (PM). It showed that the MS risk, adjusted for urbanisation and deprivation, was 29% higher among those residing in more urbanised areas.

    The study sample included over 900 MS patients within the region, and MS rates were found to have risen 10-fold in the past 50 years, from 16 cases per 100,000 inhabitants in 1974 to almost 170 cases per 100,000 people today. Whilst the huge increase can partly be explained by increased survival for MS patients, this sharp increase could also be explained by greater exposure to risk factors.
    https://medicalxpress.com/news/2020-...ple-urban.html



    bardzo dziwne, że choroby sozonowe można załatwiać metabolitem światła (Witamina D) oraz samym światłem, albo jego brakiem (Melatonina) prawda?
    i co jeśli cytokiny mają swój czas,a kluczowy moment jest jak zawsze w momencie przejścia ?
    a potencjalne leczenie będzie właśnie wydajne w tym czasie ?

    ARDS Zespół ostrej niewydolności oddechowej

    The Case for Chronotherapy in COVID-19 Induced Acute Respiratory Distress Syndrome (ARDS)



    Abstract
    COVID-19, the disease resulting from infection by a novel coronavirus: SARS-Cov2 that has rapidly spread since November 2019 leading to a global pandemic. SARS-Cov2 has infected over 4 million people and caused over 290,000 deaths worldwide. Although most cases are mild, a subset of patients develop a severe and atypical presentation of Acute Respiratory Distress Syndrome (ARDS) that is characterised by a cytokine release storm (CRS). Paradoxically, treatment with anti-inflammatory agents and immune regulators has been associated with worsening of ARDS. We hypothesize that the intrinsic circadian clock of the lung and the immune system may regulate individual components of CRS and thus chronotherapy may be used to effectively manage ARDS in COVID-19 patients.
    https://pubmed.ncbi.nlm.nih.gov/32442317/

    będąc przy nanometrach,



    co jeśli powiem, na przykładzie limfocytu, że fala mikrofalowa zaburza ten proces?

    wpierdala się w działanie kompleksu IV, wpierdala się z konsumpcje tlenu i prace rotatora V kompleksu, który z ADP robi ATP w komórkach odpornościowych, wystarczająco poważnie ?

    Exposure to 1.8 GHz electromagnetic fields affects morphology, DNA-related Raman spectra and mitochondrial functions in human lympho-monocytes
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5819811/
    +
    i takie tam inne na ten temat
    https://pubmed.ncbi.nlm.nih.gov/31218329/

    w ogólne jakie to dziwne, że bakteria, która sobie skolonizowała naszą komórkę wiele mln lat temu, ma nawet swoje DNA (mtDNA) która
    jest czuła na fale elektromegnetyczną w szczególność 800-100nm (generalnie chłonie wszystko) nagle okazje się, że pochłania fale z naszych ulubionych urządzeń .. i nie do końca jest to bezpieczne - jakie to dziwne

    więc co z tą wodą?
    zalej nasiona chia wrzątkiem i zerknij do szklanki, co tam zobaczysz ?

    a jak Cie to zainteresuje:
    correlation doesn't imply causation

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