Strona 56 z 57 PierwszyPierwszy ... 64654555657 OstatniOstatni
Pokaż wyniki od 826 do 840 z 847

Wątek: NATURALNE sposoby optymalizacji CIAŁA i DUSZY.

  1. #826
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    dzień jest jeszcze długi, więc trzeba korzystać, kolejny powód żeby ściągać koszulkę w słoneczne dni:

    było:


    https://www.researchgate.net/publica...C_channel_axis

    tymczasem:

    Adaptive thermogenesis in mice requires adipocyte light-sensing via Opsin 3

    Summary
    Almost all life forms can decode light information for adaptive advantage. Examples include the visual system, where photoreceptor signals are interpreted as images, and the circadian system, where light entrains a physiological clock. Here we describe a local, non-visual light response in mice that employs encephalopsin (OPN3, a 480 nm, blue light responsive opsin) to regulate the function of adipocytes. Germ line null and adipocyte-specific conditional null mice show a deficit in thermogenesis that is phenocopied in mice under blue-light deficient conditions. We show that blue light stimulation of adipocytes activates hormone sensitive lipase, the rate limiting enzyme in the lipolysis pathway, and that this is OPN3-dependent. Opn3 adipocyte conditional null mice also use reduced levels of fat mass when fasted and cold exposed further suggesting a lipolysis deficit. These data suggest the hypothesis that in mice, a local, OPN3-dependent light response in adipocytes is a mechanism for regulation of energy homeostasis.


    +

    Association of Exposure to Artificial Light at Night While Sleeping With Risk of Obesity in Women

    Results Among the population of 43 722 women (mean [SD] age, 55.4 [8.9] years), having any ALAN exposure while sleeping was positively associated with a higher prevalence of obesity at baseline, as measured using BMI (PR, 1.03; 95% CI, 1.02-1.03), WC (PR, 1.12; 95% CI, 1.09-1.16), WHR (PR, 1.04; 95% CI, 1.00-1.08), and WHtR (PR, 1.07; 95% CI, 1.04-1.09), after adjusting for confounding factors, with P < .001 for trend for each measure. Having any ALAN exposure while sleeping was also associated with incident obesity (RR, 1.19; 95% CI, 1.06-1.34). Compared with no ALAN, sleeping with a television or a light on in the room was associated with gaining 5 kg or more (RR, 1.17; 95% CI, 1.08-1.27; P < .001 for trend), a BMI increase of 10% or more (RR, 1.13; 95% CI, 1.02-1.26; P = .04 for trend), incident overweight (RR, 1.22; 95% CI,1.06-1.40; P = .03 for trend), and incident obesity (RR, 1.33; 95% CI, 1.13-1.57; P < .001 for trend). Results were supported by sensitivity analyses and additional multivariable analyses including potential mediators such as sleep duration and quality, diet, and physical activity.

    Conclusions and Relevance These results suggest that exposure to ALAN while sleeping may be a risk factor for weight gain and development of overweight or obesity. Further prospective and interventional studies could help elucidate this association and clarify whether lowering exposure to ALAN while sleeping can promote obesity prevention.
    https://jamanetwork.com/journals/jam...tm_term=090119

    Pozdrawiam kataboliczne !
    correlation doesn't imply causation

  2. #827
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    !! UWAGA - znachorzyca opętała lekarzy - UWAGA !!


    Anxiety and depression: Why doctors are prescribing gardening rather than drugs



    Spending time in outdoors, taking time out of the everyday to surround yourself with greenery and living things can be one of life's great joys—and recent research also suggest it's good for your body and your brain.

    Scientists have found that spending two hours a week in nature is linked to better health and well-being. It's maybe not entirely surprising then that some patients are increasingly being prescribed time in nature and community gardening projects as part of "green prescriptions" by the NHS. In Shetland for example, islanders with depression and anxiety may be given "nature pescriptions," with doctors there recommending walks and activities that allow people to connect with the outdoors.
    https://medicalxpress.com/news/2019-...ing-drugs.html


    Sleeping too much—or too little—boosts heart attack risk

    Even if you are a non-smoker who exercises and has no genetic predisposition to cardiovascular disease, skimping on sleep—or getting too much of it—can boost your risk of heart attack, according to a new University of Colorado Boulder study of nearly a half-million people.
    https://medicalxpress.com/news/2019-...sts-heart.html
    Ostatnio edytowane przez htw ; 03-09-19 o 14:19
    correlation doesn't imply causation

  3. #828
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    Cytat Zamieszczone przez htw Zobacz posta
    !! UWAGA - znachorzyca opętała lekarzy - UWAGA !!


    Anxiety and depression: Why doctors are prescribing gardening rather than drugs



    https://medicalxpress.com/news/2019-...sts-heart.html
    Study to examine health benefits of outdoor preschools



    As preschoolers across the nation head into classroom buildings for the start of the school year, more than 300 Seattle area children enrolled in the Tiny Trees Preschool will get to spend their time learning outside—rain or shine. Part of a growing trend toward nature-based early learning, outdoor preschools could very well hold the key to combatting childhood obesity. It's why one Washington State University Health Sciences researcher is partnering with Tiny Trees to study the impact of an outdoor preschool model on children's health outcomes.
    https://medicalxpress.com/news/2019-...reschools.html

    kolejne korzyści z zachodu słońca (braku słońca).

    SEPTEMBER 3, 2019
    Protective role of melatonin in early-stage and end-stage liver cirrhosis.

    The liver is composed of hepatocytes, cholangiocytes, Kupffer cells, sinusoidal endothelial cells, hepatic stellate cells (HSCs) and dendritic cells; all these functional and interstitial cells contribute to the synthesis and secretion functions of liver tissue. However, various hepatotoxic factors including infection, chemicals, high-fat diet consumption, surgical procedures and genetic mutations, as well as biliary tract diseases such as sclerosing cholangitis and bile duct ligation, ultimately progress into liver cirrhosis after activation of fibrogenesis. Melatonin (MT), a special hormone isolated from the pineal gland, participates in regulating multiple physiological functions including sleep promotion, circadian rhythms and neuroendocrine processes. Current evidence shows that MT protects against liver injury by inhibiting oxidation, inflammation, HSC proliferation and hepatocyte apoptosis, thereby inhibiting the progression of liver cirrhosis. In this review, we summarize the circadian rhythm of liver cirrhosis and its potential mechanisms as well as the therapeutic effects of MT on liver cirrhosis and earlier-stage liver diseases including liver steatosis, nonalcoholic fatty liver disease and liver fibrosis. Given that MT is an antioxidative and anti-inflammatory agent that is effective in eliminating liver injury, it is a potential agent with which to reverse liver cirrhosis in its early stage.

    wiadomo, że UV + choresterol = mocne kości, ale

    UV - Tryptofan - Serotonina = Melatonina też.

    Melatonin is a potential drug for the prevention of bone loss during space flight

    Melatonin could be a novel drug for preventing bone loss to astronauts during space flight. Here we used goldfish scales as a bone model of coexisting osteoclasts and osteoblasts and demonstrated that melatonin synthesis decreased under microgravity. Melatonin treatment of scales stimulated expression of Calcitonin, an osteoclast-inhibiting hormone, and decreased expression of an osteoclastogenesis promotor. This is the first study to report the inhibitory effect of melatonin on osteoclast activation, which is cancelled by microgravity.
    https://medicalxpress.com/news/2019-...bone-loss.html

    wszytko za darmo.

    New study confirms the long-term benefits of a low-fat diet
    https://medicalxpress.com/news/2019-...-fat-diet.html

    Effects of 8 Weeks of Caffeine Supplementation on Protein Metabolism Markers in Resistance-Trained Men
    https://journals.lww.com/acsm-msse/F...n_on.2136.aspx
    Ostatnio edytowane przez htw ; 04-09-19 o 16:34
    correlation doesn't imply causation

  4. #829
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    wydawało się komuś, że pierdole od rzeczy ?

    lektura na dzisiejszy wieczór

    POZDRIAWIAM HIPERTROFICZNIE, YO !

    The Role of the Molecular Clock in Promoting Skeletal Muscle Growth and Protecting against Sarcopenia



    Abstract: The circadian clock has a critical role in many physiological functions of skeletal muscle and is essential to fully understand the precise underlying mechanisms involved in these complex interactions. The importance of circadian expression for structure, function and metabolism of skeletal
    muscle is clear when observing the muscle phenotype in models of molecular clock disruption. Presently, the maintenance of circadian rhythms is emerging as an important new factor in human health, with disruptions linked to ageing, as well as to the development of many chronic diseases, including sarcopenia. Therefore, the aim of this review is to present the latest findings demonstrating
    how circadian rhythms in skeletal muscle are important for maintenance of the cellular physiology, metabolism and function of skeletal muscle. Moreover, we will present the current knowledge about the tissue-specific functions of the molecular clock in skeletal muscle.
    6. Conclusions
    The circadian clock has a critical role in many physiological functions of skeletal muscle and it is essential to fully understand the specific underlying bio-physiological processes that regulate these complex interactions. The importance of circadian expression for skeletal muscle structure, function and metabolism is clear when observing the muscle phenotype in models of molecular clock disruption. To confirm this, the loss of the Bmal1 gene leading to sarcopenia and several pathological muscle conditions, has been observed, including effects such as lowered mitochondria density and altered mitochondrial respiration, fibre-type shifts, impaired sarcomeric structure and restricted function [ 64 ]. However, it is important to highlight that the rescue of the Bmal1 in the skeletal muscle protected animals from the decrease in muscle mass and function [ 103 ] and, therefore, this was able to mitigate the pathological mechanisms of the skeletal muscle. An increased entrainment of skeletal muscle circadian rhythms may also contribute to systemic health. These suggests that the correct circadian expression of skeletal muscle may represent a possible target of intervention in many diseases. It is also necessary to understand how other kinds of clock disruptions, such as the desynchronization between endogenous circadian clock cycles and the exogenous light–dark cycle commonly identified in our society as “social jetlag”), could affect muscle growth and maintenance, especially in an aging population with frequent sleep disorders. Overall, it is fundamental to maintain and promote the correct functions of the muscle intrinsic clock machinery with the aim to protect against the loss of muscle during aging or in chronic disease conditions that could lead to muscle wasting. As a consequence, increased knowledge of the relationship between the skeletal muscle molecular clock and muscle-bone crosstalk may lead to a better understanding of aging-related diseases such as sarcopenia and osteoporosis
    https://sci-hub.tw/downloads/2019-09...ms20174318.pdf


    Neurogenetic basis for circadian regulationof metabolism by the hypothalamus



    Circadian rhythms are driven by a transcription-translation feedback loop that separates anabolic and catabolic processes across the Earth's 24-h light-dark cycle. Central pacemaker neurons that perceive light entrain a distributed clock network and are closely juxtaposed with hypothalamic neurons involved in regulation of sleep/wake and fast/feeding states. Gaps remain in identifying how pacemaker and extrapacemaker neurons communicate with energy-sensing neurons and the distinct role of circuit interactions versus transcriptionally driven cell-autonomous clocks in the timing of organismal bioenergetics. In this review, we discuss the reciprocal relationship through which the central clock drives appetitive behavior and metabolic homeostasis and the pathways through which nutrient state and sleep/wake behavior affect central clock function.
    https://www.ncbi.nlm.nih.gov/pubmed/...?dopt=Abstract


    At the Interface of Lifestyle, Behavior, and Circadian Rhythms: Metabolic Implications

    Nutrient metabolism is under circadian regulation. Disruption of circadian rhythms by lifestyle and behavioral choices such as work schedules, eating patterns, and social jetlag, seriously impacts metabolic homeostasis. Metabolic dysfunction due to chronic misalignment of an organism's endogenous rhythms is detrimental to health, increasing the risk of obesity, metabolic and cardiovascular disease, diabetes, and cancer. In this paper, we review literature on recent findings on the mechanisms that communicate metabolic signals to circadian clocks and vice versa, and how human behavioral changes imposed by societal and occupational demands affect the physiological networks integrating peripheral clocks and metabolism. Finally, we discuss factors possibly contributing to inter-individual variability in response to circadian changes in the context of metabolic (dys)function.

    Figure 1. The circadian regulation of hepatic gluconeogenesis illustrates an example of bi-directional regulation between clock genes and metabolism. The HPA axis is entrained to the light/dark cycle, and NAD+ availability is entrained to feeding rhythms. NAMPT facilitates NAD+ salvage pathway. NAD+ co-activates SIRT1, which then activates PGC-1α. PGC-1α activated FOXO1 is necessary for transcription of Pck1 and G6pc genes, along with the cortisol-receptor complex. Cortisol bound to its receptor entrains the clock genes to the light/dark cycle. In summary, the transcription of gluconeogenic genes (Pck1/G6pc) is regulated by cortisol-receptor complex, clocks, and FOXO1.
    https://www.frontiersin.org/articles...019.00132/full

    Morning Circadian Misalignment Is Associated With Insulin Resistance in Girls With Obesity and Polycystic Ovarian Syndrome

    Results
    All participants obtained insufficient sleep. Girls with PCOS had later clock-hour of melatonin offset, later melatonin offset relative to sleep timing, and longer duration of melatonin secretion than control subjects. A later melatonin offset after wake time (i.e., morning wakefulness occurring during the biological night) was associated with higher serum free testosterone levels and worse SI regardless of group. Analyses remained significant after controlling for daytime sleepiness and sleep-disordered breathing.

    Conclusion
    Circadian misalignment in girls with PCOS is characterized by later melatonin offset relative to clock time and sleep timing. Morning circadian misalignment was associated with metabolic dysregulation in girls with PCOS and obesity. Clinical care of girls with PCOS and obesity would benefit from assessment of sleep and circadian health. Additional research is needed to understand mechanisms underlying the relationship between morning circadian misalignment and SI in this population.
    https://academic.oup.com/jcem/articl...dFrom=fulltext

    High Dietary ω-6:ω-3 PUFA Ratio Is Positively Associated with Excessive Adiposity and Waist Circumference
    https://www.karger.com/Article/FullText/492116

    Summary of Ketogenic diet
    https://examine.com/supplements/keto...n=originalpost
    Ostatnio edytowane przez htw ; 06-09-19 o 19:32
    correlation doesn't imply causation

  5. #830
    Sztywny Pal Azji
    Dołączył
    Mar 2017
    Lokalizacja
    pomorskie
    Postów
    1 694
    Nie rozumiem, czyli, że wysypiać się już nie muszę?

  6. #831
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    paavo co z Tobą ?
    correlation doesn't imply causation

  7. #832
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    MELATONINA - hormon czasu, który informuje duszę i ciało o aktualnej pozycji (taki GPS) jest najsilniejszym i najstarszym naturalnym antyoksydantem. Jeśli tylko pozwolisz zupełnie za darmo załatwi sprawę reaktywnych form tlenu i zadba o Twój stan zapalny.

    ps. Polski wątek

    Melatonin supplementation improves oxidative and inflammatory state in the blood of professional athletes during the preparatory period for competitions.

    Abstract
    Melatonin supplementation has been proved to have antioxidant and anti-inflammatory effects in humans. The aim of the study was to estimate the influence of a 30-day melatonin supplementation on oxidative and inflammatory state in the blood of intense training professional athletes. The study was conducted in 47 football players, 19 rowers, and 15 adults who did not practice sports (control group). Blood samples were taken once from the control group and twice from the athletes: before and after 30-day melatonin administration (5 mg daily before sleep). Serum levels of melatonin, isoprostanes, antiox-LDL antibodies, interleukin-6, and C-reactive protein were measured. In erythrocytes, the concentrations of reduced glutathione (GSH) and malondialdehyde (MDA), and the activities of glutathione peroxidase (GSH-Px), cytoplasmic superoxide dismutase (SOD-1), and glutathione reductase (GR) were determined. Melatonin supplementation caused a significant decrease in markers of oxidative stress and a significant increase in melatonin concentration and the activities of SOD-1 and GSH-Px in athletes. The obtained data showed increased oxidative stress and inflammatory processes in professional athletes during intense training and indicated that supplementation of melatonin in their daily diet may have a beneficial effect on the protection of tissues against the adverse action of RONS and inflammatory processes.

    Conclusion
    Even under the physiological conditions of aerobic metabolism, RONS generated in remarkable amounts in response to strenuous effort can cause oxidative dam- age to biomolecules and muscle tissue, especially when
    the antioxidant defense systems are compromised. Our results suggest that the increase in lipid peroxidation
    and inflammatory markers and the decrease in mela-tonin are associated with strenuous training in profes-
    sional athletes. These modifications can lead to disturbances of the body functioning. The results of our
    research point that melatonin supplementation reduces peroxidation of lipids, modulates inflammatory proc- esses and strengthens the defense mechanisms against oxidative stress induced by intense physical effort.
    Additionally, taking into consideration that melatonin improves sleep efficiency, the observed effects could be at least partly associated with the improvement of the restoration process (preventing intense exercise-induced damage and injure the body) during sleep. The knowledge gained from these findings suggests
    that the use of melatonin as a supplement of daily diet by professional athletes may have a beneficial effect on the protection of tissues against the adverse action of RONS and can counteract muscle fatigue during exercise.
    https://www.tandfonline.com/doi/full...2.2018.1563688

    Bright light exposure advances consolidation of motor skill accuracy in humans.

    Abstract
    Light has attracted increasing attention as a critical determinant of memory processing. While sleep selectively consolidates newly encoded memories according to their future relevance, the role of light in human memory consolidation is largely unknown. Here, we report how bright light (BL), provided during encoding, influences online and offline consolidation of motor skill learning. We sought to determine whether relatively slower and faster key-press transitions within individuals were differentially consolidated by BL. Healthy human subjects were briefly exposed to either BL (>8000 lx) or control light (CL; <500 lx) during memory encoding at 13:00 h, when light minimally affects circadian phase-shifting, and were retested 24 h later. The effects of BL on online and offline performance gains were determined by accuracy and speed. BL-exposed subjects showed better overall performance accuracy during training and lower overnight accuracy gains after a subsequent night of sleep than did CL-exposed subjects. BL preferentially improved the initially most difficult individual key-press transitions during practice; these were only improved overnight under CL. By contrast, accuracy during what had been the easiest key-press transitions at the beginning of the experiment was unaffected by light conditions or online/offline learning processes. BL effects were not observed for performance speed, mood, or sleep-wake patterns. Brief BL exposure during training may advance motor memory selection and consolidation that optimally meet individual requirements for potential gains, which would otherwise depend on post-training sleep. This suggests a new way of enhancing brain plasticity to compensate for impaired sleep-dependent memory consolidation in neuropsychiatric conditions.
    https://www.ncbi.nlm.nih.gov/pubmed/31491556?dopt=


    Reducing the use of screen electronic devices in the evening is associated with improved sleep and daytime vigilance in adolescents


    Abstract
    The use of screen electronic devices in the evening negatively affects sleep. Yet, sleep is known to be essential for brain maturation and a key factor for good academic performance, and thus is particularly critical during childhood and adolescence. Although previous studies reported associations between screen time and sleep impairment, their causal relationship in adolescents remains unclear. Using actigraphy and daily questionnaires in a large sample of students (12 to 19 years old), we assessed screen time in the evening and sleep habits over 1 month. This included a 2 week baseline phase, followed by a 40 min sleep education workshop and a 2 week interventional phase, in which participants were asked to stop using screen devices after 9 pm during school nights. During the interventional phase, we found that the reduction of screen time after 9 pm correlated with earlier sleep onset time and increased total sleep duration. The latter led to improved daytime vigilance. These findings provide evidence that restricting screen use in the evening represents a valid and promising approach for improving sleep duration in adolescents, with potential implications for daytime functioning and health.


    Phase 1—Activities performed after 9 pm are associated with sleep during school nights. (A) Scatter plots showing significant correlation (p < .001) between screen time after 9 pm and sleep duration (N = 315; top), and hour of dim light melatonin onset (HDLMO; N = 70; bottom) during school nights. (B) Scatter plots showing no correlation (p > .5) between the time spent on off-screen activities after 9 pm and sleep duration (N = 315; top), and HDLMO (N = 70; bottom) during school nights.


    Phases 1 and 2—Association between restrictive use of screen devices after 9 pm and sleep and vigilance. (A) Mean (±SEM) time spent on screen-based activities after 9 pm during school nights for Phase 1 (grey) and Phase 2 (blue). (B) Mean (±SEM) time spent on screen-based activities after 9 pm during school nights per age group for Phase 1 and Phase 2. (C) Mean (±SEM) sleep duration during school nights for Phase 1 and Phase 2. (D) Mean (±SEM) sleep duration during school nights per age group for Phase 1 and Phase 2. (E) Scatter plot showing a significant correlation (p < .001) between the difference in time spent on screen-based activities after 9 pm (Phase 2 minus Phase 1) and the difference in sleep duration (Phase 2 minus Phase1) during school nights. (F) Mean (±SEM) reaction time (slowest 75th percentile) during the vigilance task (SART) performed at the end of Phase 1 (grey) and Phase 2 (blue). Asterisks represent significance (p) of 2-tailed paired t-tests between Phase 1 and Phase 2: **<0.001; *<0.05.
    https://academic.oup.com/sleep/artic...zsz125/5513278

    Time-controlled fasting prevents aging-like mitochondrial changes induced by persistent dietary fat overload in skeletal muscle

    A large body of evidence suggests that persistent dietary fat overload causes mitochondrial dysfunction and systemic metabolic gridlock. Mitochondrial and lipid metabolism in skeletal muscle (SkM) are severely affected upon persistent high fat diet (HFD) leading to premature tissue aging. Here, we designed weekly cycles of fasting (called as time-controlled fasting, TCF) and showed that they were effective in limiting mitochondrial damage and metabolic disturbances induced by HFD. Specifically, TCF was able to prevent the decline of adipose triglyceride lipase (Atgl), maintain efficient mitochondrial respiration in SkM as well as improve blood glucose and lipid profile. Atgl was found to be the mediator of such preventive effects as its downregulation or up-regulation in C2C12 myotubes triggers mitochondrial alteration or protects against the deleterious effects of high fat levels respectively. In conclusion, TCF could represent an effective strategy to limit mitochondrial impairment and metabolic inflexibility that are typically induced by modern western diets or during aging.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5942780/

    Understanding the Science of Resistance Training: An Evolutionary Perspective

    The history of resistance training research began with anecdotal ideas and a slow growth of research from the late 1890s through the 1970s. The mid-1970s were a nexus point when resistance training studies evolved from just strength assessments to importance in physiological systems, physical health, and physical performance capabilities for individuals interested in physical fitness through to those seeking elite athletic performances. The pursuit of understanding program design and what mediated successful programs continues today as new findings, replication of old concepts, and new visions with the latest technologies fuel both our understanding and interest in this modality. This brief review highlights some of the important scientific contributions to the evolution of our scientific study of resistance training and provides a literature base analysis for greater quantification of the origins and expanse of such investigations.
    https://link.springer.com/article/10...279-017-0779-y

    The Influence of Omega-3 Fatty Acids on Skeletal Muscle Protein Turnover in Health, Disuse, and Disease
    https://www.frontiersin.org/articles...019.00144/full

    przypominam, że robi się coraz gorzej - osoby które mają kłopoty napadami na gówno żarcie, powinny
    w szczególności uważać i czekać do 27 października (wracamy do normalności).
    Nie są to moje wymysły - neurony sytości i łaknienia (AgRP, POMOC) , które są zdeponowane w jądrze łukowatym (tak tam, gdzie odbywa się synteza dopaminy, która hamuje przysadkową prolkę) są w pełni pod kontrolą zegara. W strukturze znajdują się receptory leptyty. Żeby nie zanudzać, wątroba jest silnikiem, tarczyca pedałem gazu, a leptyna układem sterującym (medium). Jak z tkanki tłuszczonej (WAT) nie puścisz sygnału do jądra łykowatego (Arcuate nucleus) o aktualnej sytuacji energetycznej to zaczyna się jazda, nie wspominając o tępych receptorach ..

    zapraszam więc wszystkich na codzienny spektakl:

    Instalacja funkcji metabolicznych .... in progress ...









    done.

    Transcriptional Basis for Rhythmic Control of Hunger and Metabolism within the AgRP Neuron

    The alignment of fasting and feeding with the sleep/wake cycle is coordinated by hypothalamic neurons, though the underlying molecular programs remain incompletely understood. Here, we demonstrate that the clock transcription pathway maximizes eating during wakefulness and glucose production during sleep through autonomous circadian regulation of NPY/AgRP neurons. Tandem profiling of whole-cell and ribosome-bound mRNAs in morning and evening under dynamic fasting and fed conditions identified temporal control of activity-dependent gene repertoires in AgRP neurons central to synaptogenesis, bioenergetics, and neurotransmitter and peptidergic signaling. Synaptic and circadian pathways were specific to whole-cell RNA analyses, while bioenergetic pathways were selectively enriched in the ribosome-bound transcriptome. Finally, we demonstrate that the AgRP clock mediates the transcriptional response to leptin. Our results reveal that time-of-day restriction in transcriptional control of energy-sensing neurons underlies the alignment of hunger and food acquisition with the sleep/wake state.


    https://www.cell.com/cell-metabolism...131(19)30063-4
    Ostatnio edytowane przez htw ; 08-09-19 o 13:55
    correlation doesn't imply causation

  8. #833
    elo,
    jeszcze ci się nie znudziło

    oprócz tych żarówek infrared stosujesz coś zimą jak nie ma słońca?
    uvb?

  9. #834
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    Cytat Zamieszczone przez LubięFazę Zobacz posta
    elo,
    jeszcze ci się nie znudziło


    elo,
    no właśnie powoli chyba będę kończyć z działalnością,
    czuje, że się powtarzam .. a to jest głupie.

    oprócz tych żarówek infrared stosujesz coś zimą jak nie ma słońca?
    uvb?
    ja nie mam żadnego SAD'u czy innych melanopsynowych zaburzeń
    Trzeba bardzo ostrożnie z UV, ale tak kombinuje
    Ostatnio edytowane przez htw ; 08-09-19 o 14:53
    correlation doesn't imply causation

  10. #835
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    World's largest evidence review: Nutritional supplements for mental health

    The world's largest review (a meta-synthesis) of top-tier evidence, published online today in World Psychiatry, examined 33 meta-analyses of randomised control trials (RCTs) and data from 10,951 people with mental health disorders including depression, stress and anxiety disorders, bipolar disorder, personality disorders, schizophrenia and attention-deficit/hyperactivity disorder (ADHD).

    Although the majority of nutritional supplements assessed did not significantly improve mental health, the researchers found strong evidence that certain supplements are an effective additional treatment for some mental disorders, supportive of conventional treatment.

    All nutrient supplements were found to be safe when recommended dosages and prescriptive instructions were adhered to and there was no evidence of serious adverse effects or contraindications with psychiatric medications.
    https://medicalxpress.com/news/2019-...pplements.html


    Less TV, more activity may mean extra years free of heart disease and stroke

    People who watch less TV and are physically active live more years free of heart disease, according to a new study.

    Past research has shown people who are highly physically active tend to live more years free of cardiovascular disease. But researchers of a study published Monday in the Journal of the American Heart Association wanted to look specifically at how TV viewing habits fit into the equation.

    Using data from 13,534 people ages 45 to 64, investigators studied three factors—how much TV people generally watched; how often they were physically active in their leisure time; and how long they lived without having a stroke, heart failure or coronary heart disease.
    https://medicalxpress.com/news/2019-...ree-heart.html

    aktywnie metaboliczny BAT (paczka mitochondriów) jest używany jeśli z niego korzystamy w myśl zasady, nie używany organ zanika.
    BAT okazuje się ma bardzo mocny zegar. Wskazówką zegara okazuje się być EKSPRESJA NA ZIMNO.




    How circadian rhythms underlie energy production in the 'good form of fat'



    Circadian rhythms orchestrate a vast number of life's processes through the activity of a 24-hour internal clock: hormone flow, blood pressure, sleep and wake cycles, and even the timing of hibernation among marmots and bears, are controlled by a biological timepiece.

    At the University of Pennsylvania, a team of scientists has been exploring the circadian clock and its relationship to brown adipose tissue, the so-called "good" form of fat. The team has uncovered the molecular underpinnings that explain how this type of fat has a chronobiological—circadian—role in the activity of brown fat, a dynamic type of tissue that provides energy through a heat-generating process called thermogenesis.

    In humans brown fat is associated with being lean. In mice, rats and hibernating species, it's often linked with survival.

    Reporting in a recent issue of PNAS, Marine Adlanmerinia, Mitchell Lazar and a team of scientists at UPenn's Institute for Diabetes, Obesity and Metabolism, examined the circadian nature of brown adipose fat tissue (BAT) in mice that were exposed to an exceptionally cold temperature for several days.

    "Regulation of body temperature in response to cold environments is controlled by thermogenic brown adipose tissue, particularly in rodents, although it is increasingly clear that humans have functional brown adipocytes," reported Adlanmerinia and her team.

    Among humans and other mammals, BAT is one of two types of fat; the other is white adipose tissue, or WAT. In humans, WAT, the type of fat associated with big rumps and beer bellies, fuels a global obesity epidemic. BAT, on the other hand, is not as common among people as it is in other species, particularly rodents. In people, BAT diminishes with age.

    Babies have a high distribution of BAT compared with adults, and infants do not shiver when they are cold. They depend, instead, on thermogenesis, heat production from brown fat to keep them warm. The act of shivering in adults—shivering thermogenesis—increases body heat.

    In humans, BAT is usually found in the nape of the neck and guarding vital organs, such as the kidneys. Although adults have a lower distribution of BAT than babies, people who are obese have even less BAT than those who are lean. It is theorized by some experts who study BAT that brown fat may help maintain leaness. By comparison, a range of studies over the years has shown that mice with ample BAT reserves are protected from obesity.

    In the UPenn research, mice were subjected for to a temperature of 4 degrees Celsius, or 39.2 degrees Fahrenheit, for a week. The team showed how circadian-driven fat synthesis in brown adipose tissue maintained a healthy body temperature in the test mice.

    Adlanmerinia and colleagues also identified genes controlling de novo lipogenesis, brown fat formation that was triggered anew to protect the animals from chronic cold during the experiment. The scientists noted "high-amplitude circadian rhythms in thermogenic BAT."

    "We demonstrate that chronic cold temperature causes new circadian rhythms of de novo lipogenesis in brown adipose tissue," Adlanmerinia and the team wrote in the journal.

    BAT differs from white fat not only because it responds to cold temperatures, but because it is also chock-full of mitochondria, the energy-production powerhouses of cells. The bean-shaped mitochondria cells, which have two membranes, also have a high concentration of thermogenin, a heat-generating protein, in the second membrane.

    Experiments similar to the UPenn research have shown that when BAT increases in mice and other rodents, the animals are better-armed to withstand cold.
    https://medicalxpress.com/news/2019-...roduction.html

    stres + jedzenie ?

    Stress eating causes more weight gain than stress-free snacking

    A new study warns that eating while stressed may cause you to gain more weight than eating the same amount of calories in the absence of stress. The effect was linked to a molecular pathway in the brain that was controlled by insulin, according to the study, underscoring the importance of avoiding food as a way to deal with stress and negative emotions.
    https://www.slashgear.com/stress-eat...king-26574889/


    gówno żarcie uszkadza mózg - prowadzi do stanu zapalnego centrum metabolicznego.


    High-fat, high-carbohydrate diets affect your brain, not just your physical appearance

    Much research has pointed to how an unhealthy diet correlates to obesity, but has not explored how diet can bring about neurological changes in the brain. A recent Yale study has discovered that high-fat diets contribute to irregularities in the hypothalamus region of the brain, which regulates body weight homeostasis and metabolism.

    Led by Sabrina Diano, the Richard Sackler Family Professor of Cellular & Molecular Physiology and professor of neuroscience and comparative medicine, the study evaluated how the consumption of a high-fat diet—specifically diets that include high amounts of fats and carbohydrates—stimulates hypothalamic inflammation, a physiological response to obesity and malnutrition.
    https://medicalxpress.com/news/2019-...ect-brain.html
    Ostatnio edytowane przez htw ; 09-09-19 o 18:43
    correlation doesn't imply causation

  11. #836
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    wrzeń - marzec czas na grypę, zapalenie płuc i inne przyjemności

    kiedy nie ma jetlagu - kiedy dużo słońca, czyli wakacje:


    https://www.cell.com/current-biology...822(18)31345-9

    tak tak:

    Circadian control of lung inflammation in influenza infection

    Abstract
    Influenza is a leading cause of respiratory mortality and morbidity. While inflammation is essential for fighting infection, a balance of anti-viral defense and host tolerance is necessary for recovery. Circadian rhythms have been shown to modulate inflammation. However, the importance of diurnal variability in the timing of influenza infection is not well understood. Here we demonstrate that endogenous rhythms affect survival in influenza infection. Circadian control of influenza infection is mediated by enhanced inflammation as proven by increased cellularity in bronchoalveolar lavage (BAL), pulmonary transcriptomic profile and histology and is not attributable to viral burden. Better survival is associated with a time dependent preponderance of NK and NKT cells and lower proportion of inflammatory monocytes in the lung. Further, using a series of genetic mouse mutants, we elucidate cellular mechanisms underlying circadian gating of influenza infection.
    https://www.nature.com/articles/s41467-019-11400-9

    2019 Aug 21
    Time-Restricted Feeding Improves Glucose Tolerance in Rats, but Only When in Line With the Circadian Timing System.

    Abstract
    Epidemiological studies indicate that shift-workers have an increased risk of type 2 diabetes mellitus (T2DM). Glucose tolerance and insulin sensitivity both are dependent on the circadian timing system (i.e., the time-of-day) and fasting duration, in rodents as well as humans. Therefore, question is whether manipulation of the circadian timing system, for example by changing the timing of feeding and fasting, is a potential preventive treatment for T2DM. Time-restricted feeding (TRF) is well-known to have profound effects on various metabolic measures, including glucose metabolism. However, experiments that directly measure the effects of TRF on glucose tolerance and/or insulin sensitivity at different time points throughout the 24 h cycle are lacking. Here we show, in rats, that TRF in line with the circadian timing system (i.e., feeding during the active phase) improves glucose tolerance during intravenous glucose tolerance tests (ivGTT) in the active phase, as lower insulin levels were observed with similar levels of glucose clearance. However, this was not the case during the inactive phase in which more insulin was released but only a slightly faster glucose clearance was observed. Contrasting, TRF out of sync with the circadian timing system (i.e., feeding during the inactive phase) worsened glucose tolerance, although only marginally, likely because of adaptation to the 4 week TRF regimen. Our results show that TRF can improve glucose metabolism, but strict adherence to the time-restricted feeding period is necessary, as outside the regular eating hours glucose tolerance is worsened.
    https://www.ncbi.nlm.nih.gov/pubmed/...medium=twitter
    correlation doesn't imply causation

  12. #837
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    problemy z insuliną ? problemy z cukrem ?

    WYŁĄCZ PC i TELEFON po zachodzie.

    Suppression of Blue Light at Night Ameliorates Metabolic Abnormalities by Controlling Circadian Rhythms.

    Abstract
    PURPOSE:
    Light-emitting diodes that emit high-intensity blue light are associated with blue-light hazard. Here, we report that blue light disturbs circadian rhythms by interfering with the clock gene in the suprachiasmatic nucleus (SCN) and that suppression of blue light at night ameliorates metabolic abnormalities by controlling circadian rhythms.

    METHODS:
    C57BL/6J mice were exposed to 10-lux light for 30 minutes at Zeitgeber time 14 for light pulse with blue light or blue-light cut light to induce phase shift of circadian rhythms. Phase shift, clock gene expression in SCN, and metabolic parameters were analyzed. In the clinical study, healthy participants wore blue-light shield eyewear for 2 to 3 hours before bed. Anthropometric data analyses, laboratory tests, and sleep quality questionnaires were performed before and after the study.

    RESULTS:
    In mice, phase shift induced with a blue-light cut light pulse was significantly shorter than that induced with a white light pulse. The phase of Per2 expression in the SCN was also delayed after a white light pulse. Moreover, blood glucose levels 48 hours after the white light pulse were higher than those after the blue-cut light pulse. Irs2 expression in the liver was decreased with white light but significantly recovered with the blue-cut light pulse. In a clinical study, after 1 month of wearing blue-light shield eyeglasses, there were improvements in fasting plasma glucose levels, insulin resistance, and sleep quality.

    CONCLUSIONS:
    Our results suggest that suppression of blue light at night effectively maintains circadian rhythms and metabolism.
    https://www.ncbi.nlm.nih.gov/pubmed/...?dopt=Abstract

    smutek, lęk, przygnębienie ...

    Social media use by adolescents linked to internalizing behaviors

    A new study from researchers at the Johns Hopkins Bloomberg School of Public Health found that adolescents who spend more than three hours a day on social media are more likely to report high levels of internalizing behaviors compared to adolescents who do not use social media at all.
    https://medicalxpress.com/news/2019-...rnalizing.html
    correlation doesn't imply causation

  13. #838
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    Wiemy, dlaczego z wiekiem przybieramy na wadze

    Wiele osób z wiekiem przybiera na wadze, nawet jeśli nie zmienili ani diety, ani poziomu aktywności fizycznej. Badacze z Karolinska Institutet właśnie odkryli, dlaczego tak się dzieje. Okazuje się, że z wiekiem zmniejsza się tempo przemiany lipidów i ludzie łatwiej przybierają na wadze.

    Na potrzeby badań naukowcy na przestrzeni 13 lat badali komórki tłuszczowe grupy 54 mężczyzn i kobiet. W tym czasie, niezależnie od tego czy dana osoba przytyła, czy też nie, u wszystkich zauważono zmniejszenie intensywności przemiany lipidowej. Ci, którzy nie skompensowali tego przyjmowaniem mniejszej ilości kalorii, przybrali na wadze średnio o 20%, informują naukowcy.

    Do badań zaangażowano również 41 kobiet, które przeszły operację bariatryczną, a naukowcy analizowali, jak tempo przemiany lipidowej wpływało na utrzymanie przez nie wagi w ciągu 4–7 lat po operacji. Okazało się, że tylko u tych kobiet, u których przed operacją przemiana lipidowa była powolna doszło po operacji do jej przyspieszenia i tylko te pacjentki były w stanie utrzymać wagę. Uczeni sądzą, że takie osoby mają większe szanse na przyspieszenie przemiany lipidowej niż ci, u których przed operacją była ona na wysokim poziomie.

    Nasze badania są pierwszymi, które pokazują, że procesy zachodzące w naszej tkance tłuszczowej są czynnikiem, który – niezależnie od innych – reguluje masę działa. To może pomóc z znalezieniu nowych metod leczenia otyłości, mówi profesor Peter Arner, jeden z głównych autorów badań.

    Już wcześniejsze badania wykazały, że jednym ze sposobów na przyspieszenie przemiany lipidowej jest zwiększona aktywność fizyczna. Obecne badania wspierają to spostrzeżenie i pokazują, że długoterminowy spadek wagi po operacji bariatrycznej jest możliwy o ile pacjenci zwiększą poziom aktywności fizycznej. Otyłość i związane z nią choroby są problemem globalnym. Zrozumienie dynamiki lipidów oraz mechanizmów regulujących rozmiary tkanki tłuszczowej są niezwykle przydatne, dodaje Kirsty Spalding, badaczka z Karolinska Institutet.


    https://youtu.be/ja-MWkFNvDg
    +
    https://youtu.be/OyQ1cgBw8HA?list=PL...wo8doDJavTFOvg
    +
    https://youtu.be/jxylGoJP9jY?list=PL...wo8doDJavTFOvg

    +

    info o chylomikronach IDL, LDL, i HDL
    https://youtu.be/wQY0xpwqPfQ?list=PL...wo8doDJavTFOvg

    +

    wisienka na torcie:

    Brain leptin reduces liver lipids by increasing hepatic triglyceride secretion and lowering lipogenesis
    https://www.nature.com/articles/s41467-019-10684-1
    correlation doesn't imply causation

  14. #839
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    najczęstszy mechanizm do robienia formy życia:

    Exercising while restricting calories could be bad for bone health

    A new study published today in the Journal of Bone and Mineral Research shows how bones in mammals are negatively impacted by calorie restriction, and particularly by the combination of exercise and calorie restriction. Maya Styner, MD, associate professor of medicine at the UNC School of Medicine, is the senior author on the study.
    https://medicalxpress.com/news/2019-...ne-health.html

    a później się okuję, że nieruchome i bez finezji kości robią takie rzeczy:

    Bone, not adrenaline, drives fight or flight response

    When faced with a predator or sudden danger, the heart rate goes up, breathing becomes more rapid, and fuel in the form of glucose is pumped throughout the body to prepare an animal to fight or flee.

    These physiological changes, which constitute the "fight or flight" response, are thought to be triggered in part by the hormone adrenaline.

    But a new study from Columbia researchers suggests that bony vertebrates can't muster this response to danger without the skeleton. The researchers found in mice and humans that almost immediately after the brain recognizes danger, it instructs the skeleton to flood the bloodstream with the bone-derived hormone osteocalcin, which is needed to turn on the fight or flight response.

    "In bony vertebrates, the acute stress response is not possible without osteocalcin," says the study's senior investigator Gérard Karsenty, MD, Ph.D., chair of the Department of Genetics and Development at Columbia University Vagelos College of Physicians and Surgeons.

    "It completely changes how we think about how acute stress responses occur."
    https://phys.org/news/2019-09-bone-a...-response.html

    Possible application of melatonin treatment in human diseases of the biliary tract.

    Melatonin was discovered in 1958 by Aaron Lerner; its name comes from the ability of melatonin to change the shape of amphibian melanophores from stellate to roundish. Starting from the 80s, the role of melatonin in the regulation of mammalian circadian and seasonal clocks has been elucidated. Presently, several other effects have been identified in different organs. For example, he beneficial effects of melatonin in models of liver damage have been described. This review gives first a general background on experimental and clinical data on the use of melatonin in liver damage. The second part of the review focuses on the findings related to the role of melatonin in biliary functions suggesting a possible use of melatonin therapy in human diseases of the biliary tree.
    https://www.ncbi.nlm.nih.gov/pubmed/...ct&utm_source=

    Melatonin and Multiple Sclerosis: From Plausible Neuropharmacological Mechanisms of Action to Experimental and Clinical Evidence.

    Multiple sclerosis (MS) is a devastating chronic autoimmune demyelinating disease of the central nervous system (CNS), thought to affect more than 2.5 million people worldwide. Regulation of the sleep-wake cycle might influence disease activity and the frequency of relapses in patients. As melatonin (or sleep hormone) involves the regulation of circadian rhythms, much attention has been paid to the management of MS symptoms with melatonin. This review describes the pharmacological mechanisms underlying the neuroprotective effects of melatonin and recent clinical evidence from MS patients. Apparent risks and benefits of melatonin therapies are also discussed. Various in vivo and clinical data presented in this up-to-date review suggest that melatonin may possibly possess a protective role against the behavioral deficits and neuropathological characteristics of MS. Multiple mechanisms of the neuroprotective effects of melatonin such as mitochondrial protection and antioxidant, anti-inflammatory, and anti-apoptotic properties, as well as its anti-demyelinating function are also discussed. A large body of evidence shows that melatonin potently regulates the immune system, demyelination, free radical generation, and inflammatory responses in neural tissue, which are mediated by multiple signal transduction cascades. In the present article, we focus on different pathways that are targeted by melatonin to prevent the development and progression of MS.
    https://www.ncbi.nlm.nih.gov/pubmed/...?dopt=Abstract


    Suppression of Blue Light at Night Ameliorates Metabolic Abnormalities by Controlling Circadian Rhythms.

    PURPOSE:
    Light-emitting diodes that emit high-intensity blue light are associated with blue-light hazard. Here, we report that blue light disturbs circadian rhythms by interfering with the clock gene in the suprachiasmatic nucleus (SCN) and that suppression of blue light at night ameliorates metabolic abnormalities by controlling circadian rhythms.

    METHODS:
    C57BL/6J mice were exposed to 10-lux light for 30 minutes at Zeitgeber time 14 for light pulse with blue light or blue-light cut light to induce phase shift of circadian rhythms. Phase shift, clock gene expression in SCN, and metabolic parameters were analyzed. In the clinical study, healthy participants wore blue-light shield eyewear for 2 to 3 hours before bed. Anthropometric data analyses, laboratory tests, and sleep quality questionnaires were performed before and after the study.

    RESULTS:
    In mice, phase shift induced with a blue-light cut light pulse was significantly shorter than that induced with a white light pulse. The phase of Per2 expression in the SCN was also delayed after a white light pulse. Moreover, blood glucose levels 48 hours after the white light pulse were higher than those after the blue-cut light pulse. Irs2 expression in the liver was decreased with white light but significantly recovered with the blue-cut light pulse. In a clinical study, after 1 month of wearing blue-light shield eyeglasses, there were improvements in fasting plasma glucose levels, insulin resistance, and sleep quality.

    CONCLUSIONS:
    Our results suggest that suppression of blue light at night effectively maintains circadian rhythms and metabolism.
    https://www.ncbi.nlm.nih.gov/pubmed/...=Abstract&utm_

    Circadian gene PER1 senses progesterone signal during human endometrial decidualization.

    Progesterone is an important hormone for female reproduction, however, how the fluctuation of progesterone acts upon reproductive processes remains largely unknown. Mounting evidence indicates a pivotal role of the circadian clock in sensing hormone dynamics for homeostatic regulation of physiological functions. Therefore, we sought to determine whether clock genes respond to progesterone signaling in female reproductive system. In this study, we tested the hypothesis that the circadian system could respond to progesterone signaling during human endometrial decidual transformation. The expression of the circadian gene PER1 increased immediately and remained elevated during human endometrial decidualization. The progesterone receptor activated PER1 transcription by directly binding to its promoter from the onset of the stromal proliferation-differentiation transition. PER1 knockout significantly downregulated the expression of some PGR target genes, and attenuated human endometrial decidual transformation by expediting FOXO1 protein degradation. In conclusion, progesterone could control the female reproductive process through sustained feedback from the circadian gene PER1, which is probably involved to P4-PR signaling responsiveness in the initiation and maintenance of decidualization.
    https://www.ncbi.nlm.nih.gov/pubmed/...=Abstract&utm_


    https://t.co/mSycUoOJfb?amp=1
    correlation doesn't imply causation

  15. #840
    Sztywny Pal Azji
    Dołączył
    May 2014
    Postów
    1 797
    An update on sleep in bipolar disorders: presentation, comorbidities, temporal relationships and treatment.

    Abstract
    Sleep and circadian rhythms have been implicated in the onset, course, and treatment of bipolar disorder. The aim of the present review is to provide an update on emerging understandings of the role of sleep in BD. Recent research in this population has provided further clarity around the prevalence of sleep problems and comorbidities, their relationship to mood symptoms and other clinical features, and their assessment and treatment. A number of important trends are highlighted: the need for more granularity in the characterisation of sleep problems, the potentially disruptive role of commercial sleep monitoring technologies in assessment and treatment, and the urgent need for further research into pharmacological and psychosocial strategies to treat sleep problems in bipolar disorder.
    https://www.ncbi.nlm.nih.gov/pubmed/...act&utm_source



    Study suggests human growth hormone can reverse epigenetic aging

    A team of researchers affiliated with several institutions in the U.S. and one in Canada has found evidence that suggests recombinant human growth hormone (rhGH) can reverse epigenetic aging in humans. In their paper published in the journal Aging Cell, the group describes their efforts to learn more about the impact of rhGH on the thymus, and what they found.

    The researchers report that their interest in the impact of rhGH on the thymus began when they came across a report describing research in 1986 that showed injecting rats with rhGH boosted their immune system. One of the team members, Gregory Fany, actually tested the idea on himself back in the 1990s, and found that that it appeared to rejuvenate his thymus, which boosted his immune system.

    The thymus is a gland in the chest that converts white blood cells to T cells and therefore plays an important role in immune response. Unfortunately, as humans age, fatty deposits develop in the thymus, along with reductions in human growth hormone—the result is weakened immune responses. In this new effort, the researchers wanted to get a better idea of what happens to the thymus and the immune system if people are given rhGH. To find out, they recruited nine volunteers, all white males, to participate in their study.

    The study consisted of giving each of the volunteers the growth hormone DHEA. Each was also given two drugs to ward off diabetes, since DHEA had been found to trigger the disease. The volunteers were monitored over the course of a year. At the end of the year, the researchers found that seven of the nine volunteers had lost fat in their thymuses and that healthy tissue had regrown to replace it. On a whim, the researchers also conducted epigenetic marker (methylation) testing on the volunteers, as well. They report that all 10 of the volunteers experienced reverse epigenetic aging—on average, they grew biologically younger by two and a half years.

    The researchers note that their study was very limited, and because of that, more studies are required to determine if human growth hormone can actually reverse the aging process.
    https://medicalxpress.com/news/2019-...pigenetic.html

    jak odwrócić epigenetyczny wiek ?

    Dbać o korę nadnerczy, gdzie następuje produkcja eliksiru młodości DHEA

    więcej:


    niezła beka jest w środku

    czyli dbać o Yin and Yang:


    https://www.nature.com/articles/s41574-019-0228-0

    + spać jak kamień:


    https://www.ncbi.nlm.nih.gov/pmc/art...297368/?page=4

    z rzeczy super podstawowych oczywiście.
    correlation doesn't imply causation

Uprawnienia umieszczania postów

  • Nie możesz zakładać nowych tematów
  • Nie możesz pisać wiadomości
  • Nie możesz dodawać załączników
  • Nie możesz edytować swoich postów
  •  

Dołącz do nas na FB

Partnerzy

MMA odzywki sklep plany treningowe spalacz tłuszczu legginsy