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Wątek: NATURALNE sposoby optymalizacji CIAŁA i DUSZY.

  1. #886
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    sezon jesienny, uwaga znowu wkracza zegar:

    naukowcy z Washington University School of Medicine w St. Louis zidentyfikowali rodzaj komórki odpornościowej, która pomaga utrzymać czas w jelitach.

    Scientists find timekeepers of gut's immune system



    An immune cell that helps set the daily rhythms of the digestive system has been identified by researchers at Washington University School of Medicine in St. Louis. The findings open the door to new treatments for digestive ailments targeting such cells. Credit: Qianli Wang
    As people go through their daily and nightly routines, their digestive tracts follow a routine, too: digesting food and absorbing nutrients during waking hours, and replenishing worn-out cells during sleep. Shift work and jet lag can knock sleep schedules and digestive rhythms out of whack. Such disruptions have been linked to increased risk of intestinal infections, obesity, inflammatory bowel disease and colorectal cancer, among others.

    Now, researchers at Washington University School of Medicine in St. Louis have identified a type of immune cell that helps keep time in the gut. Such cells, known as type 3 innate lymphoid cells (ILC3), are responsible for keeping the intestine operating in a normal, healthy manner. The researchers found that so-called clock genes are highly active in such cells and that the cells' production of immune molecules track with the activity of the clock genes. When the researchers eliminated a key clock gene from mice, the animals failed to produce a subset of ILC3 cells and struggled to control a bacterial infection in the gut.
    https://medicalxpress.com/news/2019-...ut-immune.html

    Fish in early childhood reduces risk of disease

    It doesn't take that much fish for young children to reap big health benefits. Even eating fish just once a week yields good results.
    Children should be introduced to fish or cod liver oil early in life, from when they are about a year old. That's because children who consume fish early on show significantly reduced occurrences of eczema, wheezing and asthma at age six, as reported by their parents.
    The reduction ranges from 28 to 40 percent fewer occurrences for the various conditions.
    https://medicalxpress.com/news/2019-...d-disease.html

    Omega-3 fish oil supplements linked with lower cardiovascular disease risk

    People who received omega-3 fish oil supplements in randomized clinical trials had lower risks of heart attack and other cardiovascular disease (CVD) events compared with those who were given placebo, according to a new meta-analysis from Harvard T.H. Chan School of Public Health and Brigham and Women's Hospital. Researchers found an association between daily omega-3 supplementation and reduced risk of most CVD outcomes, including heart attack, death from coronary heart disease, and death from CVD, but did not see benefit for stroke. In addition, higher doses of omega-3 fish oil supplements appeared to provide even greater risk reduction.
    https://www.sciencedaily.com/release...0930161922.htm

    Zachód słońca w Nowej Hucie - kto by pomyślał ...
    fot. @tomrollauer

    Ostatnio edytowane przez htw ; 05-10-19 o 17:00
    correlation doesn't imply causation

  2. #887
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    metoda Wima Hof'a "na propsie" jak się to mówi

    Nobel z medycyny za gospodarkę tlenową w komórkach



    Instytut Karoliński w Sztokholmie przyznał tegoroczną nagrodę Nobla w dziedzinie fizjologii lub medycyny za odkrycie mechanizmów, w jaki sposób komórki odczuwają i adaptują się do zmian dostępności tlenu. Nagrodą podzielą się po równo Amerykanin William G. Kaelin Jr., Brytyjczyk Sir Peter J. Ratcliffe i Amerykanin Gregg L. Semenza. Tlen ma kluczowe znaczenie dla procesów przemiany materii. Tegorocznych laureatów wyróżniono za odkrycie procesów regulacji aktywności genów, które pozwalają organizmowi dopasowywać się do zmian poziomu tlenu. Ich prace pomogły w tworzeniu nowych metod terapii anemii, raka i wielu innych chorób. Ich ubocznym skutkiem jest doping sportowy z wykorzystaniem EPO.

    Czytaj więcej na https://www.rmf24.pl/nauka/news-nobe...ampaign=chrome
    przypominam:

    correlation doesn't imply causation

  3. #888
    [/QUOTE]

    w tez rzece płynie płetwal błękitny.

  4. #889
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    zastosowanie intensywnego światła (PER2) w leczeniu chorób sercowo-naczyniowych.

    yhm, kardio-protekcyjne zastosowanie wschodu słońca.

    AUGUST 06, 2019
    Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium

    +

    a co muszę robić właściciele piesków - wychodzić z nimi rano na spacerek.

    Dog ownership associated with longer life, especially among heart attack and stroke survivors

    Dog ownership may be associated with longer life and better cardiovascular outcomes, especially for heart attack and stroke survivors who live alone, according to a new study and a separate meta-analysis published in Circulation: Cardiovascular Quality and Outcomes, a journal of the American Heart Association.
    https://medicalxpress.com/news/2019-...ife-heart.html

    Cytat Zamieszczone przez Mastif Zobacz posta


    w tez rzece płynie płetwal błękitny.
    faktycznie, w dodatku na sterydach chyba bo jakiś przerośnięty
    Ostatnio edytowane przez htw ; 08-10-19 o 10:43
    correlation doesn't imply causation

  5. #890
    Szefie na obecna pogode za oknem witamina D3 cos pomoze ? bo rano jak zombie sie czuje :P

  6. #891
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    Cytat Zamieszczone przez ziki2000 Zobacz posta
    Szefie na obecna pogode za oknem witamina D3 cos pomoze ?
    bo rano jak zombie sie czuje




    za chuj NIE, przecież notorycznie o tym piszę

    To problem elektromagnetyczny. Zobacz co się dzieje ze wschodem słońca:
    https://www.timeanddate.com/sun/poland/warsaw

    do normalności wracamy 26 października - słońca z rana będzie znowu więcej.
    Oczywiście trzeba korzystać z tego faktu i wychodzić rano na zewnątrz, min 30 min, Ziki w Twoim specyficznym przypadku pewnie więcej. Miedzy 12 - 13 wypadałoby się również pojawiać na zewnątrz (nawet w pochmurny dzień).

    A wieczorem chronić szyszynkę:

    Ostatnio edytowane przez htw ; 09-10-19 o 12:34
    correlation doesn't imply causation

  7. #892
    OK 20 jade na wczasy to nadrobie :P
    A mozesz przypomniec czemu nie dawać witaminy D ?? :>

  8. #893
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    OK 20 jade na wczasy to nadrobie :P
    i to jest rozwiązanie. To gdzie rano wylądują Twoje oczy jest najważniejsze, trzeba oddzielić NOC od DNIA w tej kolejności. Jak jesteś z tych co muszą organoleptyczne pomacać żeby się przekonać, zainstaluj w telefonie jakąś aplikację do mierzenie luksów - LuxMeter coś w ten deseń, ustaw czujnik do nieba i zobacz jaką masz wartość, jak jest więcej niż 10 000 j to jesteś w domu - mózg otrzymuje informację że mamy dzień.

    Cytat Zamieszczone przez ziki2000 Zobacz posta
    A mozesz przypomniec czemu nie dawać witaminy D ?? :>
    dlatego:



    albo tak:



    ścieżka nie jest prosta jak widać.

    historia z witaminą D zaczyna się po tym jak 300 nm dotyka cholesterolu (na skórze) Są rejony na świecie gdzie mamy mało ultrafioletu (półkula północna) i tam mam jako ekwiwalent tłuste ryby.

    więc dawać możesz - ale to zwyczajna strata czasu (oczywiście są momenty gdzie suplementacja może pomóc ale to skrajne przypadki).
    Suplementowanie witaminy D ma taki sens jak kupowanie na placu prawa jazdy i oczekiwanie, że możesz bezpiecznie poruszać się po drodze.
    Ostatnio edytowane przez htw ; 09-10-19 o 13:28
    correlation doesn't imply causation

  9. #894
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    kiedy się robi ciśnienie na gówno żarcie ? oczywiście jak kimka nie wyjdzie.
    Na jakiej zasadzie się to dzieje?

    otóż:

    Craving junk food after a sleepless night? Blame your nose, which sniffs out high fat, calorie-dense food

    When you're sleep deprived, you tend to reach for doughnuts, fries and pizza. A new Northwestern Medicine study has figured out why you crave more calorie-dense, high-fat foods after a sleepless night—and how to help thwart those unhealthy choices.

    Blame it on your nose—or olfactory system—which is affected in two ways by sleep deprivation, according to the study. First, it goes into hyperdrive, sharpening the food odors for the brain so it can better differentiate between food and non-food odors.
    But then there is a breakdown in the communication with other brain areas that receive food signals. And with that, decisions about what to eat change.
    "When you're sleep deprived, these brain areas may not be getting enough information, and you're overcompensating by choosing food with a richer energy signal," said senior author Thorsten Kahnt, assistant professor of neurology at Northwestern University Feinberg School of Medicine.
    "But it may also be that these other areas fail to keep tabs on the sharpened signals in the olfactory cortex. That could also lead to choosing doughnuts and potato chips," Kahnt added.
    The paper was published Oct. 8 in eLife.
    Past research shows sleep deprivation increases certain endocannabinoids, which are naturally produced by the body and are important for feeding behavior and how the brain responds to odors, including food smells.
    "We put all this together and asked if changes in food intake after sleep deprivation are related to how the brain responds to food odors, and whether this is due to changes in endocannabinoids," Kahnt said. "What makes our brain respond differently that makes us eat differently?"
    He and colleagues investigated that question in a two-part experiment with 29 men and women, ages 18 to 40. Study participants were divided into two groups. One got a normal night's sleep, then four weeks later, were only allowed to sleep for four hours. The experience was reversed for the second group. The day after each night (good sleep and deprived sleep), scientists served participants a controlled menu for breakfast, lunch and dinner, but then also offered them a buffet of snacks. Scientists measured how much and what they ate.
    "We found participants changed their food choices," Kahnt said. "After being sleep deprived, they ate food with higher energy density (more calories per gram) like doughnuts, chocolate chip cookies and potato chips."
    Researchers also measured the participants' blood levels of two endocannabinoid compounds—2AG and 2OG. One of the compounds, 2-OG, was elevated after the night of sleep deprivation and this increase was related to changes in food selection.
    In addition, scientists put subjects in an fMRI scanner before the buffet. They then presented them with a number of different food odors and non-food control odors while they observed the piriform cortex, the first cortical brain region that receives input from the nose.
    They observed that activity in the piriform cortex differed more between food and non-food odors when subjects were sleep deprived.
    The piriform cortex normally sends information to another brain area, the insular cortex. The insula receives signals that are important for food intake, like smell and taste, and how much food is in the stomach.
    But the insula of a sleep-deprived subject showed reduced connectivity (a measure of communication between two brain regions) with the piriform cortex. And the degree of this reduction was related to the increase in 2-OG and how much subjects changed their food choices when sleep deprived.
    "When the piriform cortex does not properly communicate with the insula, then people start eating more energy-dense food," Thorsten said.
    The solution? Other than getting more sleep, it may help to pay closer attention to how our nose sways our food choices.
    "Our findings suggest that sleep deprivation makes our brain more susceptible to enticing food smells, so maybe it might be worth taking a detour to avoid your local doughnut shop next time you catch a 6 a.m. flight," Kahnt said.
    układ endokannabinoidowy oczywiście ma swój rytm:

    Circadian Rhythm of Circulating Levels of the Endocannabinoid 2-Arachidonoylglycerol

    To our knowledge, this is the first study to examine concentrations of the most abundant endogenous ligand of the CB1 receptor, 2-AG, across the 24-hour period with rigorous control of energy intake, activity level, dark-light timing, and sleep-wake schedule in humans. The data reveal that the activity of the eCB system is profoundly modulated by circadian rhythmicity. We indeed observed a robust circadian rhythm of circulating concentrations of 2-AG, an endogenous ligand of the CB1 and CB2 receptors, with a nadir around the middle of the sleep/overnight fast and an extended period of maximal levels in the early to midafternoon. Levels of 2-AG increased, on average, more than 3-fold from nocturnal nadir to early afternoon acrophase. The return to lower nocturnal concentrations was not initiated until late afternoon or early evening.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399498/

    tak, słońce się chowa więc będziemy częściej sięgać po gówno żarcie.

    notabene - liczy się jakość:

    People who eat more meals at home have lower levels of harmful PFAS in their bodies

    A home-cooked meal has many benefits, including healthier ingredients and fewer processed foods. But there's another reason to avoid eating out all the time. Preparing meals at home can reduce your exposure to harmful PFAS chemicals that are commonly found in take-out and fast food packaging, according to a new study by researchers at Silent Spring Institute.
    https://medicalxpress.com/news/2019-...as-bodies.html

    nie masz motywacji do ćwiczeń fizycznych - wyjdź rano na spacer:

    Six minutes of walking can increase motivation to perform physical activity

    A home-cooked meal has many benefits, including healthier ingredients and fewer processed foods. But there's another reason to avoid eating out all the time. Preparing meals at home can reduce your exposure to harmful PFAS chemicals that are commonly found in take-out and fast food packaging, according to a new study by researchers at Silent Spring Institute.
    https://medicalxpress.com/news/2019-...as-bodies.html
    Ostatnio edytowane przez htw ; 09-10-19 o 14:30
    correlation doesn't imply causation

  10. #895
    Po nocce zawsze jest ciśnienie na słodkie i śmieciowe żarcie

  11. #896
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    Cytat Zamieszczone przez semozo Zobacz posta
    Po nocce zawsze jest ciśnienie na słodkie i śmieciowe żarcie
    ponieważ jesteś mieszkańcem planety Ziemia



    Witamy na pokładzie


    ps.
    wcale nie trzeba być pracownikiem zmiany nocnej żeby mieć jetlaga.
    Ostatnio edytowane przez htw ; 09-10-19 o 16:33
    correlation doesn't imply causation

  12. #897
    Ja nie mam cisnienia na slodkie. Moze dlatego ze 3lata tluszczowa dieta ale jestem drazliwy

  13. #898
    htw
    czy dieta ketogeniczna jest dobra dla leczenia insulinooporności ? bo tak często można się spotkać z tezą że keto nie dla cukrzyków...
    jakie masz zdanie na ten temat ?

  14. #899
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    Cytat Zamieszczone przez maly mis Zobacz posta
    Ja nie mam cisnienia na slodkie. Moze dlatego ze 3lata tluszczowa dieta ale jestem drazliwy
    wtedy jest troszkę inaczej to fakt.

    Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice

    Objective
    A network of endogenous circadian clocks adapts physiology and behavior to recurring changes in environmental demands across the 24-hour day cycle. Circadian disruption promotes weight gain and type 2 diabetes development. In this study, we aim to dissect the roles of different tissue clocks in the regulation of energy metabolism.

    Methods
    We used mice with genetically ablated clock function in the circadian pacemaker of the suprachiasmatic nucleus (SCN) under different light and feeding conditions to study peripheral clock resetting and the role of the peripheral clock network in the regulation of glucose handling and metabolic homeostasis.

    Results
    In SCN clock-deficient mice, behavioral and non-SCN tissue clock rhythms are sustained under rhythmic lighting conditions but deteriorate quickly in constant darkness. In parallel to the loss of behavioral and molecular rhythms, the animals develop adiposity and impaired glucose utilization in constant darkness. Restoring peripheral clock rhythmicity and synchrony by time-restricted feeding normalizes body weight and glucose metabolism.

    Conclusions
    These data reveal the importance of an overall synchronized circadian clockwork for the maintenance of metabolic homeostasis.
    https://www.sciencedirect.com/scienc...12877819309159

    odsypiasz w weekend ?

    Sleep debt: the impact of weekday sleep deprivation on cardiovascular health in older women

    Results
    Mean age was 72.1 ± 6.0 years. Compared to women with no sleep debt, women with sleep debt were more likely to be obese and have hypertension (pall < .05). Linear regression models adjusted for age and race/ethnicity revealed that sleep debt was significantly associated with poorer ICH (B = –0.13 [95% CI = –0.18 to –0.08]). The relationship was attenuated but remained significant after adjustment for education, income, depression/anxiety, cumulative stress, and snoring.

    Conclusion
    Sleep debt was associated with poorer ICH, despite taking into account socioeconomic status and psychosocial factors. These results suggest that weekly sleep duration variation, possibly leading to circadian misalignment, may be associated with cardiovascular risk in older women.
    https://www.ncbi.nlm.nih.gov/pubmed/31361895

    Adding red light to artificial lungs to reduce carbon monoxide in poisoned patients

    A team of researchers at Massachusetts General Hospital and Harvard Medical School has found that it is possible to remove carbon monoxide (CO) from blood by shining a red light on it as it moves through an artificial lung. In their paper published in the journal Science Translational Medicine, they describe their device and how well it worked during testing on rats.

    Carbon monoxide poisoning is one of the most common types of accidental poisonings. The gas is produced during fires and explosions. When inhaled, it can damage organs and quite often kill the victim. The odorless gas is so dangerous because it displaces oxygen from hemoglobin, resulting in oxygen starvation throughout the body. The current treatment for CO poisoning is administration of 100 percent oxygen, sometimes in a hyperbaric chamber. Such treatments, unfortunately, are not fast enough to prevent damage. Because of that, scientists have been looking for ways to remove CO from the blood faster. In this new effort, the researchers used red light.

    Scientists discovered over 100 years ago that shining a red light on blood can break the bonds between CO and hemoglobin, allowing oxygen to take its place. But a means of using light to help carbon monoxide patients has not been thoroughly examined until now.
    https://medicalxpress.com/news/2019-...gs-carbon.html

    za dużo syntetycznych witamin ?

    Too much vitamin B can cause hip fracture

    Many healthy individuals take high doses of vitamin B supplements. They take them to be on the safe side, thinking that it must be good for their health. The scope of this varies greatly from country to country. It is not common to sell high doses of vitamin B in Norway, but they are nevertheless easy to obtain via the Internet.
    However, the high doses have no health-enhancing effect on otherwise healthy people. You only need to take supplements when you have a vitamin B deficiency.
    https://medicalxpress.com/news/2019-...-fracture.html

    The role of sex and sex Hormones in Neurodegenerative Diseases

    Neurodegenerative diseases (NDs) are a wide class of disorders of the central nervous system (CNS) with still unknown etiology. Several factors were hypothesized to be involved in the pathogenesis of these diseases including genetic and environmental factors. Many of these diseases show a sex prevalence and sex steroids where shown to have a role in the progression of specific forms of neurodegeneration. Estrogens were reported to be neuroprotective though their action on cognate nuclear and membrane receptors, while adverse effects of male hormones have been described on neuronal cells, although some data also suggest neuroprotective activities. The response of the CNS to sex steroids is a complex and integrated process that depends on: i.) the type and amount of the cognate steroid receptor; ii.) the target cell-type, either neurons, glia or microglia. Moreover, the levels of sex steroids in the CNS fluctuate due to gonadal activities and to local metabolism and synthesis. Importantly, biochemical processes involved in the pathogenesis of NDs are increasingly being recognized different among the two sexes and to be influenced by sex steroids.

    The aim of this review is to present current state-of-the-art understanding on the potential role of sex steroids and their receptors on the onset and progression of major neurodegenerative disorders, namely Alzheimer’s disease, Parkinson’s diseases, Amyotrophic Lateral Sclerosis and the peculiar motoneuron disease Spinal and Bulbar Muscular Atrophy, in which hormonal therapy is potentially useful as disease modifier.
    https://academic.oup.com/edrv/advanc...dFrom=fulltext

    ziki jakbyś jakbyś wychodził rano na zewnątrz i dalej byś się czuł jak kupa, trzeba sobie będzie kupić sprzęt:

    Strategies to decrease social jetlag: Reducing evening blue light advances sleep and melatonin
    https://onlinelibrary.wiley.com/doi/...1111/ejn.14293
    correlation doesn't imply causation

  15. #900
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    Co to jest Rispolept?

    Atypowy lek przeciwpsychotyczny, pochodna benzizoksazolu, stosowany w leczeniu schizofrenii i innych chorób psychicznych.

    Co zawiera i jak działa Rispolept?

    Substancją czynną preparatu jest rysperydon. Mechanizm jego działania polega na oddziaływaniu na określone receptory w mózgu. Wykazuje duże powinowactwo do receptorów serotoninowych (5-HT2), dopaminowych (D2), adrenergicznych (a1 i słabsze do a2) oraz histaminowych (H1). Nie wykazuje powinowactwa do receptorów cholinergicznych ani β-adrenergicznych. Silne blokowanie receptorów dopaminowych D2 powoduje zmniejszenie objawów wytwórczych schizofrenii; rysperydon w porównaniu z klasycznymi neuroleptykami słabiej hamuje czynności ruchowe i wykazuje słabsze działanie kataleptyczne. Ponieważ działa z równą siłą zarówno na receptory serotoninowe, jak i dopaminowe w ośrodkowym układzie nerwowym, może zmniejszać ryzyko wystąpienia pozapiramidowych działań niepożądanych oraz rozszerzyć działanie terapeutyczne na objawy negatywne schizofrenii oraz na objawy zaburzeń afektywnych.
    https://www.mp.pl/pacjent/leki/lek/4...etki-powlekane


    USA – W wyniku stosowania leku Risperdal mężczyźnie urosły piersi, Johnson&Johnson w ramach zadośćuczynienia może zapłacić 8 miliardów dolarów

    Ława przysięgłych w Filadelfii zasądziła 8 miliardów dolarów zadośćuczynienia od firmy Johnson&Johnson dla mężczyzny, któremu urosły piersi w wyniku stosowania leku Risperdal – informuje Reuters.
    https://losyziemi.pl/usa-w-wyniku-st...iardow-dolarow

    Chrząstka w ludzkich stawach może się regenerować, jeśli zrozumie się mechanizm regeneracji, będzie możliwe opracowanie metod leczenia choroby zwyrodnieniowej stawów

    Chrząstka w ludzkich stawach może regenerować się w procesie podobnym do tego, w jakim salamandrom odrastają utracone kończyny, donoszą naukowcy z Duke University. W ostatnim numerze Science Advances opisali oni mechanizm odtwarzania się tkanki chrzęstnej. Wydaje się, że lepiej działa on w stawie skokowym, a gorzej w stawie biodrowym. Zrozumienie mechanizmu regeneracji może doprowadzić do opracowania metod leczenia choroby zwyrodnieniowej stawów, najbardziej rozpowszechnionej na świecie choroby atakującej stawy u człowieka.
    https://losyziemi.pl/chrzastka-w-lud...eniowej-stawow

    czy geny zegarowe modulują przestrzeń synaptyczną ? TAK.
    sen reguluje ostatni etap budowania białka w celu zbudowania solidnych synaps.
    https://www.scientificamerican.com/a...rain-proteins/

    oksytocyna - gaśnica kortyzolu, czyżby ?

    Tying the knot is tied to longer life span, new data shows



    (HealthDay)—Married folks not only live longer than singles, but the longevity gap between the two groups is growing, U.S. government health statisticians report.

    The age-adjusted death rate for the married declined by 7% between 2010 and 2017, according to a new study from the National Center for Health Statistics (NCHS), part of the U.S. Centers for Disease Control and Prevention.
    "Not only is the rate for married lower, but it's declining more than any other group," said lead author Sally Curtin, an NCHS statistician.
    https://medicalxpress.com/news/2019-...life-span.html
    correlation doesn't imply causation

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