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Wątek: NATURALNE sposoby optymalizacji CIAŁA i DUSZY.

  1. #481
    Cytat Zamieszczone przez htw Zobacz posta
    Sztuczne słodziki są toksyczne dla bakterii mikrobiomu jelitowego
    http://losyziemi.pl/sztuczne-slodzik...omu-jelitowego

    dobra tyle się udało .. dobranoc.
    Widzę dalej, że niestety jedynym Twoim celem jest rzucanie clickbaitowych linków, bez zapoznania się z badaniem byle wyrobić normę. "Nauka" dla debili niestety.

    Powyższe "badanie" ma następujące czynniki, które podważają jakąkolwiek wiarygodność:

    - wiele naturalnych, potrzebnych organizmowi substancji jest toksyczna dla bakterii, jak np. zwyczajna sól
    - badanie nie pokazuje w żaden sposób, że bakterie przestały się namnażać, jedyne co pokazano, to że zmienia się jak mocno wytwarzają światło
    - badanie nie badało żadnego mikrobu jelitowego, tylko pojedyncze szczepy bakterii na płytce
    - nie podano odniesienia, co jest kompletnie ośmieszające

    "we may speculate that the response observed in our study may be relevant to gut microbiome and thus may influence human health"

    'we may we may thus may' - Filozofowanie na podstawie badania, które ma pełno wad w założeniu i wykonaniu.

    Jedyne co zyskuje na tym, to posiadacze portali, gdzie takie 'badania' generują przychody z reklam.

  2. #482
    Poczciwy dzik
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    Cytat Zamieszczone przez LSC79 Zobacz posta
    odpowiedź to sen polifazowy.

    Btw, Htw słyszałeś kiedyś o żywieniu optymalnym?
    Kwaśniewski ?
    http://dr-kwasniewski.pl/

    byłem na stronie:

    insulina jest hormonem przyspieszającym rozwój miażdżycy i jest jednym z najbardziej rakotwórczych czynników
    Jeżeli człowiek jest głodny i nie je, to zawsze płaci za to wysoką cenę. Cena jest tym wyższa, im post lub głodówka trwa dłużej. Jest to nie tylko cena osłabienia zdrowia i odporności, ale gorzej pracuje wtedy mózg, słabną uczucia, źle ocenia się otaczającą rzeczywistość, traci się energię życiową, łatwo popada się w uzależnienie od ludzi i nałogów, krótko mówiąc — człowiek staje się głupszy, prymitywnieje umysłowo.
    o ja pierdole

    nie mam zdania na temat snu polifazowego, nie czytałem badań nie zagłębiałem się. Z tego co się orientuję chodzi o drzemki w ciągu dnia, żeby ograniczyć spanie w nocy ? może na krótką metę, może w określonym celu - jako metoda wojskowa ... może ... - długofalowo ---> ? imho katastrofa. Jeśli są na Ziemi obszary w których bywają częste zaćmienia słońca i trwało to odpowiednio długo, takie organizmy miały szanse się przystosować, to spoko.

    People often struggle if they have to adjust to working the night shift, but their genes have even more trouble. According to a new study from McGill University, genes that are accustomed to daytime rhythm usually fail to adapt to nighttime rhythm, possibly contributing to health problems such as diabetes, obesity, and cardiovascular disease—disorders that are more frequently seen in night-shift workers.

    Many genes that regulate important biological processes have a sort of sleeping/waking cycle, one that increases or decreases gene expression over a 24-hour period. This cycle may be assessed globally, for all genes, via characterization of the transcriptome, the set of all mRNAs expressed by the genome.

    In the McGill University study, transcriptomes were evaluated for eight healthy volunteers who were artificially subjected to a five-day schedule simulating night-shift work. In a time-isolation room, the volunteers were deprived of any light or sound cues characteristic of the time of day and were not allowed to use their phones or laptops.

    On the first day and after the last night shift, the volunteers provided blood samples at regular intervals for a period of 24 hours. These samples were then subjected to a transcriptomic analysis that encompassed the expression of more than 20,000 genes.

    The results of this work appeared May 7 in the Proceedings of the National Academy of Sciences (PNAS), in an article entitled “Simulated Night Shift Work Induces Circadian Misalignment of the Human Peripheral Blood Mononuclear Cell Transcriptome.” The article describes how imposing a night-shift schedule dampened gene expression rhythms, resulting in a “desynchrony between rhythmic transcripts and the shifted the sleep/wake cycle.”

    "Almost 25% of the rhythmic genes lost their biological rhythm after our volunteers were exposed to our night-shift simulation,” noted Nicolas Cermakian, Ph.D., director of the Laboratory of Molecular Chronobiology at the Douglas Mental Health University Institute (DMHUI) and a full professor at McGill University's Department of Psychiatry. “And 73% did not adapt to the night shift and stayed tuned to their daytime rhythm. Less than 3% partly adapted to the night-shift schedule."

    "We now better understand the molecular changes that take place inside the human body when sleeping and eating behaviors are in sync with our biological clock,” added Diane B. Boivin, M.D., Ph.D., a researcher at DMHUI and another author of the PNAS paper. “For example, we found that the expression of genes related to the immune system and metabolic processes did not adapt to the new behaviors.”

    “Functional analysis,” the authors of the PNAS paper wrote, “revealed that key biological processes are affected by the night shift protocol, most notably the natural killer cell-mediated immune response and Jun/AP1 and STAT pathways.”

    As the study was conducted under highly controlled conditions in the laboratory, future research should extend these findings by studying the gene expression of actual night-shift workers whose physical activity, food intake, and timing of sleep might differ from one another. This could also be applied to other people that are at risk of experiencing biological clock misalignment, such as travelers crossing time zones on a frequent basis.

    "We think the molecular changes we observed potentially contribute to the development of health problems like diabetes, obesity, and cardiovascular diseases more frequently seen in night-shift workers on the long term," explained Dr. Boivin. However, she adds this will require further investigation.

    Every Single Cell in Your Body Is Controlled by Its Own Circadian Clock

    Early-morning sluggishness, or the havoc wrecked by jet lag - it’s all down to your circadian rhythm. But how does your biological timekeeping actually work? It turns out that nearly every cell in the human body keeps time by its own means. From your hair cells and skin to your muscles and even kidneys, there are trillions of cellular clocks everywhere in the body.

    In most organisms, the circadian rhythm has a roughly 24-hour period, thanks to the planet we’ve all evolved on. You know that your circadian rhythms respond to the cycle of light and dark, but that’s only the external input. When it comes to translating a sunny morning into feeling alert, that input needs to be registered by the master clock in the brain. Here, in the hypothalamus, right above the crossing of your two optical nerves, lies a tiny patch of about 20,000 neurons called the suprachiasmatic nucleus.

    For a long time it was thought this is where the biological clock is located. However, it turns out that the brain only contains the circadian rhythm central, from which hormonal signals travel all over the body, synchronising the cells to the day-night cycle. Individual cells have their own little clocks that keep time locally, making sure enzymes are produced, blood pressure is under control, cells are dividing, and so on.

    This biological timekeeping is actually a genetic process, and we share it with many bacteria, plants, animals, and even fungi. At a cellular level we have a range of 'clock genes' that code for clock proteins - daily interactions between them causes protein level fluctuations in the cell, in turn influencing cell activity.

    Because the centralised clock keeps everything in sync, sometimes you get random bouts of hunger when jet-lagged, because the ‘local stomach clock’ is disconnected from the brain for a few days, until the whole system realigns again.

    "Almost every cell in our body has a circadian clock," Salk Institute circadian researcher Satchin Panda told Veronique Greenwood at Quanta Magazine. "It helps every cell figure out when to use energy, when to rest, when to repair DNA, or to replicate DNA."

    One vivid example is hair cells - in 2013 Panda and his colleagues discovered that mouse hair grows fast in the morning, and slows down at night, when it repairs cell damage instead. They hypothesised that this has real implications for cancer patients who receive radiotherapy - if they are treated in the morning, that’s when cells are not repairing, which leads to hair loss.

    "While we don't yet know if human hair follows that same clock we found in mice hair, it is true that facial hair in men grows during the day, resulting in the proverbial 5 o'clock shadow. There is no 5am shadow if you shave at night," says Panda.

    There are other uses for our knowledge of clock genes. Some of them regulate cell death and proliferation, two processes that are disrupted in cancer tissue - where clock genes and proteins don’t seem to be present.

    Studying our cellular clocks can also help us understand how to align hormonal medication to a patient’s circadian rhythm, the best ways to treat jet lag or sleep disorders, and even explain why older people have disrupted sleep patterns - it could be that their central clock gets out of sync with the rest of the body. Cellular clocks are nearly everywhere for a good reason - without these little genetic mechanisms your body would be a hot mess.
    noc wcale nie jest nudna:





    a jak koryzol straci rytmiczność ?


    https://www.cell.com/cell-metabolism...131(18)30190-6

    konsekwencja:



    i w ogóle:

    Rytmy okołodobowe kontrolują metabolizm lipidów i aminokwasów w mięśniach szkieletowych:

    Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock


    https://journals.plos.org/plosbiolog...l.pbio.2005886


    i raz jeszcze



    Cytat Zamieszczone przez Jony8304
    O proszę:
    http://lubimyczytac.pl/ksiazka/31235...ne-zycie-drzew

    PS:
    Przepraszam że jeszcze nie śpię.
    Atakowana roślina reaguje. Kiedy zjada ją zwierzę albo owad, jej układ odpornościowy w innych częściach także staje się aktywny.

    https://www.focus.pl/artykul/rosliny...zwierzat-wideo



    Cytat Zamieszczone przez fazzeerr Zobacz posta
    Widzę dalej, że niestety jedynym Twoim celem jest rzucanie clickbaitowych linków, bez zapoznania się z badaniem byle wyrobić normę. "Nauka" dla debili niestety.

    Powyższe "badanie" ma następujące czynniki, które podważają jakąkolwiek wiarygodność:

    - wiele naturalnych, potrzebnych organizmowi substancji jest toksyczna dla bakterii, jak np. zwyczajna sól
    - badanie nie pokazuje w żaden sposób, że bakterie przestały się namnażać, jedyne co pokazano, to że zmienia się jak mocno wytwarzają światło
    - badanie nie badało żadnego mikrobu jelitowego, tylko pojedyncze szczepy bakterii na płytce
    - nie podano odniesienia, co jest kompletnie ośmieszające

    "we may speculate that the response observed in our study may be relevant to gut microbiome and thus may influence human health"

    'we may we may thus may' - Filozofowanie na podstawie badania, które ma pełno wad w założeniu i wykonaniu.

    Jedyne co zyskuje na tym, to posiadacze portali, gdzie takie 'badania' generują przychody z reklam.
    oczywiście, że nie czytam wnikliwie każdego badania do niusa które mi wpadnie w oko,jak znajdę czas, którego nie mam czytam o oscylatorach peryferyjnych.
    Wklejam tutaj niusy nie ze względu na normę, nikt mi nie płaci, większość ma mnie głęboko w dupie i uważa za wariata Wklejam i osoba zainteresowana czyta, jak czuje potrzebę zgłębienia to super i wtedy np odpowiada - dokładnie jak Ty to zrobiłeś, bardzo merytorycznie przy okazji - celne uwagi, tylko nie wiem skąd ta nadmierna emocjonalność jeśli urażam Twoją inteligencje to wybacz Don Corleone.

    niestety jedynym Twoim celem jest rzucanie clickbaitowych linków
    moim jedynym celem jest zainteresowanie
    Ostatnio edytowane przez htw ; 10-10-18 o 08:00
    correlation doesn't imply causation

  3. #483
    Ja nie twierdzę, że Ty dostajesz za to pieniądze, ale nie rozumiem sensu tematu, gdzie wrzucasz wszystko co popadnie bez weryfikacji. "Badania naukowe" nie zawsze są dobre, szczególnie gdy są sponsorowane przez jakieś lobby, które chce badanie takie, żeby potwierdzić korzystną dla siebie tezę lub gdy autorzy próbują przebić się i robią to samo, tyle że bez nawet prekursora dla takiej czynności jakim jest odpowiednia ilość gotówki.

    Jeśli z tego ma być jakakolwiek korzyść, trzeba protokołów i rozwiązań. Wdrożeń. Co z tego, że pojedyncze komórki reagują jakoś na płytce Peltiera na monochromatyczne światło o długości 623.323234 nm, polaryzacji kołowej prawoskrętnej, jeśli w realiach życiowych tego się nie da w żaden sposób odtworzyć. Nie wyciągniesz swoich mikrobów z jelita i nie będziesz na nie świecił laserem z zestawem polaryzatorów.

    Można wyciągać wnioski i szukać sposobów na przestrzeni globalnej, makroskopowej.

    Ja nie jestem przeciwny ogólnie szukaniu, tylko przeciwny jestem wyciąganiu wniosków po zdaniu z nagłówka i sprowadzaniu nauki do "SŁODZIK RAK POWODUJE", "ŚWIATŁO LECZY BIAUKOCHOLIZM" itp. Bo to prowadzi do tego, że ludzie przestają ufać nauce, bo "naukowcy wciąż nic nie wiedzą", "to jeszcze nic nie wiadomo, tam ciągle się zmienia" itp. A to nie prawda, zmienia to się modny nagłówek w telewizji i portalach internetowych. Badania trwają, poważni naukowcy nie wyciągają wniosków na podstawie badania korespondencyjnego na 8 osobach.

    A trzeba dodać, że badania na ludziach są trudne. Bo kwestie moralne, kwestia kosztów (jeśli kontrolować grupę ludzi, to sensowne badanie polega na trzymaniu ich w ośrodku/hotelu, a wyżywienie itp dla powiedzmy 500 osób przez kilka miesięcy to są wielkie koszty.

    Np. jeśli wiadomo, że ludzie mają chronicznie podniesiony kortyzol, to zamiast lasera do jelita grubego żeby świecić na bakterie, to można koty pooglądać Albo lepiej sobie sprawić jednego albo dwa do domu.



    https://www.youtube.com/watch?v=cWf3vzHVXBc
    Ostatnio edytowane przez fazzeerr ; 10-10-18 o 08:25

  4. #484
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    zgadam się, mam tego świadomość:

    przykład oczywistości:

    Study reveals how sex 'blindspot' could misdirect medical research

    “This was a scientific blindspot that we really thought needed exploration. A person’s sex has a significant impact on the course and severity of many common diseases, and the consequential side effects of treatments – which are being missed. Now we have a quantitative handle on how much sexual dimorphism has an impact in biomedical research. In the movement towards precision medicine, we not only have to account for genetic differences between people when we consider disease, but also their sex.”




    https://www.sanger.ac.uk/news/view/s...dical-research


    a nawet język i kraj z jakiego będzie pochodzić badanie może mieć wpływ na ostateczny wynik:




    eh można by pisać i pisać.
    Ostatnio edytowane przez htw ; 10-10-18 o 09:12
    correlation doesn't imply causation

  5. #485

  6. #486
    Poczciwy dzik
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    Cytat Zamieszczone przez Siła Zobacz posta


    bolało mnie to - ale trudno się mówi ale jedno zdanie mi się spodobało - aminokwasy aromatyczne pochłaniają ultrafiolet od tego powinien zacząć.


    w alternatywie:
    Photoendocrinology. How natural & artificial light is impacting human’s endocrine system & hormones
    https://vimeo.com/187834155

    +




    zima idzie więc raz jeszcze, naruszony zegar = maciek


    https://www.frontiersin.org/articles...017.00558/full


    "dopaminowe spierdolenie"(jednostka chorobowa) = ograniczone możliwości aktualizacji wiedzy


    October 10, 2018, European College of Neuropsychopharmacology
    Scientists show change in beliefs associated with dopamine in brain



    For the first time, scientists have been able to image brain activity when people change their short-term beliefs, and to relate this brain activity to dopamine function in humans. UK scientists monitored brain activity when people changed simple beliefs about the causes of their perceptions, but the results may have important implications for understanding how the brain supports the formation of more general beliefs. This work is presented at ECNP Congress in Barcelona, and at the same time is published in the peer-reviewed journal, PNAS.

    One of the most challenging problems that the brain solves is to accurately represent the external environment (form beliefs about it), and to update this representation in the face of new sensory evidence. Previous work, particularly in rodents, has identified that the neurotransmitter dopamine might be involved in this process, however there has been no direct evidence of this in humans, partly due to the difficulty in measuring dopamine function in humans.

    A group of UK scientists asked a group of healthy volunteers to undergo brain scans while performing a task which required them to update beliefs about the environment. As research lead Matthew Nour (at University College London and Kings College London') said:

    "We form beliefs about the world based on the information we get from our senses. When our sensory perceptions surprise us, it could mean that the world has changed and this might cause us to update our beliefs. For example, if we are told that it's sunny outside, and then we hear raindrops, then we modify our belief. We can use functional brain imaging to investigate what is happening in the brain when people update their beliefs in this way ".

    In this study, the volunteers were asked to respond to a series of sounds and images which were sometimes surprising, and caused them to change their beliefs about the task environment. Nour's team used fMRI (functional Magnetic Resonance Imaging, high resolution brain scanners similar to those used in hospitals) to measure changes in brain activity while these beliefs were changing, and importantly also measured activity in the dopamine system using PET scans (Positron Emission Tomography, which uses a small amount of radioactive tracer to measure dopamine receptors in the brain) to relate brain activity to dopamine function.

    Matthew Nour continued:

    "We found that two key brain areas of the dopamine system (the midbrain and striatum) appear to be more active when a person updates their beliefs about the world, and this activity is related to measures of dopamine function in these regions".

    Whilst previous studies had related dopamine function to learning about rewards, the present study is the first to directly show that dopamine might play a broader role in updating beliefs more generally in humans.

    "This work may have several implications. We know for example that some medicines and some drugs of abuse cause significant changes in dopamine signaling in the brain. Cocaine and amphetamine, for example, increase brain dopamine release and can cause significant changes in our perceptions and beliefs about the surrounding world. Some psychiatric disorders are also associated with abnormal dopamine function. Our study shows how brain dopamine function might play a role in belief updating, and therefore helps us to understand how abnormal beliefs might arise in certain mental health conditions, and perhaps in everyday life.", Matthew Nour added.

    Commenting, Professor Kamilla Miskowiak (University of Copenhagen) said:

    "This is an interesting neuroimaging study that points to a key role of dopamine activity in how we update our beliefs about the world. In psychiatric disorders like schizophrenia, problems with updating beliefs about the world seem to contribute to psychotic symptoms like delusions. The findings of this study therefore improve our understanding of how dopamine dysregulation in these disorders impacts on psychotic symptoms and why medication with actions on dopamine attenuate these symptoms".
    October 10, 2018, British Medical Journal
    Planned intermittent fasting may help reverse type 2 diabetes, suggest doctors

    Planned intermittent fasting may help to reverse type 2 diabetes, suggest doctors writing in the journal BMJ Case Reports after three patients in their care, who did this, were able to cut out the need for insulin treatment altogether.

    Around one in 10 people in the US and Canada have type 2 diabetes, which is associated with other serious illness and early death. It is thought to cost the US economy alone US$245 billion a year.

    Lifestyle changes are key to managing the disease, but by themselves can't always control blood glucose levels, and while bariatric surgery (a gastric band) is effective, it is not without risk, say the authors. Drugs can manage the symptoms, and help to stave off complications, but can't stop the disease in its tracks, they add.

    Three men, aged between 40 and 67, tried out planned intermittent fasting to see if it might ease their symptoms. They were taking various drugs to control their disease as well as daily units of insulin. In addition to type 2 diabetes, they all had high blood pressure and high cholesterol.

    Two of the men fasted on alternate days for a full 24 hours, while the third fasted for three days a week. On fast days they were allowed to drink very low calorie drinks, such as tea/coffee, water or broth, and to eat one very low calorie meal in the evening.

    Before embarking on their fasting regime, they all attended a 6-hour long nutritional training seminar, which included information on how diabetes develops and its impact on the body; insulin resistance; healthy eating; and how to manage diabetes through diet, including therapeutic fasting.

    They stuck to this pattern for around 10 months after which fasting blood glucose, average blood glucose (HbA1c), weight, and waist circumference were re-measured.

    All three men were able to stop injecting themselves with insulin within a month of starting their fasting schedule. In one case this took only five days.

    Two of the men were able to stop taking all their other diabetic drugs, while the third discontinued three out of the four drugs he was taking. They all lost weight (by 10-18%) as well as reducing their fasting and average blood glucose readings, which may help lower the risk of future complications, say the authors.

    Feedback was positive, with all three men managing to stick to their dietary schedule without too much difficulty.

    This is an observational study, and refers to just three cases-all in men. As such, it isn't possible to draw firm conclusions about the wider success or otherwise of this approach for treating type 2 diabetes.

    "The use of a therapeutic fasting regimen for treatment of [type 2 diabetes] is virtually unheard of," write the authors. "This present case series showed that 24-hour fasting regimens can significantly reverse or eliminate the need for diabetic medication," they conclude.
    Ostatnio edytowane przez htw ; 11-10-18 o 06:56
    correlation doesn't imply causation

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